Nature Search

Tolerability and effect of inhibiting microfibrillar-associated protein 4 in small intestinal anastomotic healing

Rasmus Refshauge Andresen
Jesper Brandt Pedersen
Grith Lykke Sorensen
ResearchOpen Access29 Nov 2025
Scientific Reports

Volume: 16, P: 1-15
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease

Gene editing of hematopoietic stem and progenitor cells offers promise as a curative treatment for chronic granulomatous disease (CGD). Here, the authors develop a D10A Cas9n based gene editing strategy to treat CGD with no detectable off-target activity or chromosomal translocations.

Jonas Holst Wolff
Thomas Wisbech Skov
Jacob Giehm Mikkelsen
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-16
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor

Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling.

Bao-cun Zhang
Alice Pedersen
Søren R. Paludan
Research19 Sept 2025
Nature Immunology

Volume: 26, P: 1916-1930
Importance of an N-terminal structural switch in the distinction between small RNA-bound and free ARGONAUTE

ARGONAUTE (AGO) is the core protein component of small RNA-guided silencing complexes. Free, but not RNA-bound, AGO turns over rapidly. The authors identify a structural AGO switch whose accessibility only in the free state confers rapid degradation.

Simon Bressendorff
Ida Marie Zobbe Sjøgaard
Peter Brodersen
Research07 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 625-638
Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk

This study uses cryo-EM, biochemical, and computational approaches to shed light on the fundamental mechanisms underlying the human mitoribosome function, including ligand binding, modifications, Fe-S clusters, and aging-related polyamines.

Vivek Singh
Yuzuru Itoh
Alexey Amunts
ResearchOpen Access20 May 2024
Nature Communications

Volume: 15, P: 1-22
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR

A high-throughput chemical screen identifies the salt-inducible kinase inhibitor HG-9-91-01 as a driver of β cell proliferation, acting through an ATF6-dependent unfolded protein response.

Jérémie Charbord
Lipeng Ren
Olov Andersson
Research20 May 2021
Nature Metabolism

Volume: 3, P: 682-700
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inflammatory response to SARS-CoV-2 infection.

David Olagnier
Ensieh Farahani
Christian K. Holm
ResearchOpen Access02 Oct 2020
Nature Communications

Volume: 11, P: 1-12
A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes

Chromatin-associated protein complexes play a critical role in the regulation of gene expression in health and disease. Here, the authors describe a sensitive mass spectrometry-based method to monitor the dynamic interactions of endogenous chromatin-associated protein complexes in clinical samples.

Evangelia K. Papachristou
Kamal Kishore
Jason S. Carroll
ResearchOpen Access13 Jun 2018
Nature Communications

Volume: 9, P: 1-13
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

The use of oncolytic viruses as a therapy for cancer is limited by mechanisms inhibiting viral replication in the tumor. Here, the authors show that a chemical derivative of itaconate, 4-octyl itaconate, increases oncolytic virus VSVΔ51 efficacy in various cancer models, through decreasing antiviral immunity.

Naziia Kurmasheva
Aida Said
David Olagnier
ResearchOpen Access15 May 2024
Nature Communications

Volume: 15, P: 1-28
TMEFF1 is a neuron-specific restriction factor for herpes simplex virus

A study identifies TMEFF1 as a neuron-specific restriction factor essential for prevention of replication of herpes simplex virus type 1 in the central nervous system.

Yao Dai
Manja Idorn
Søren R. Paludan
Research24 Jul 2024
Nature

Volume: 632, P: 383-389
MYC activity at enhancers drives prognostic transcriptional programs through an epigenetic switch

This paper highlights the mechanisms underlying MYC-dependent gene regulation from transcriptional enhancers, which are distinct to the function of MYC at promoters. This process takes place in a cancer type-specific way, and the resulting transcriptional programs can predict prognosis.

Simon T. Jakobsen
Rikke A. M. Jensen
Rasmus Siersbæk
Research07 Mar 2024
Nature Genetics

Volume: 56, P: 663-674
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Stimulator of interferon genes (STING) is known to be involved in defence against DNA viruses, but its role in the control of RNA viruses remains poorly explored. Here the authors show that STING participates in an innate immune response to RNA virus infection in a cGAS-independent manner.

Christian K. Holm
Stine H. Rahbek
Søren R. Paludan
ResearchOpen Access19 Feb 2016
Nature Communications

Volume: 7, P: 1-9
STEEP mediates STING ER exit and activation of signaling

STING ER exit is the rate-limiting step in STING signaling, but the mechanism that drives this process is not understood. Paludan and colleagues identify CxORF56, called STEEP here, as a positive regulator of STING signaling.

Bao-cun Zhang
Ramya Nandakumar
Søren R. Paludan
Research20 Jul 2020
Nature Immunology

Volume: 21, P: 868-879
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

ARID1A and other SWI/SNF components are critical for response to estrogen-receptor antagonists in breast cancer. SWI/SNF-specific gene knockouts lead to drug resistance and ARID1A mutations are more frequent in resistant tumors from patients.

Sankari Nagarajan
Shalini V. Rao
Jason S. Carroll
Research06 Jan 2020
Nature Genetics

Volume: 52, P: 187-197
DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

The AAA ATPase p97 (VCP) is thought to remove specific proteins from chromatin at sites of DNA damage, to allow proper repair or processing, but how p97 targets those sites was unclear. The protein DVC1 is now shown to localize to sites of replication stress and UV-light damage, and to be required for p97 recruitment. DVC1's localization to DNA damage sites requires its UBZ domain and PCNA-interacting motif but not PCNA ubiquitination. DVC1 deficiency caused retention of error-prone translesion polymerase η at foci after UV-light damage and increased mutagenesis levels.

Anna Mosbech
Ian Gibbs-Seymour
Niels Mailand
Research07 Oct 2012
Nature Structural & Molecular Biology

Volume: 19, P: 1084-1092
De novo mutations in familial adenomatous polyposis (FAP)

Rasmus Ripa
Marie Luise Bisgaard
Finn Cilius Nielsen
Research02 Oct 2002
European Journal of Human Genetics

Volume: 10, P: 631-637
SAM68 directs STING signaling to apoptosis in macrophages

The signaling protein SAM68 mediates apoptosis in macrophages downstream of stimulator of interferon genes (STING) activation.

Demi van der Horst
Naziia Kurmasheva
David Olagnier
ResearchOpen Access07 Mar 2024
Communications Biology

Volume: 7, P: 1-15
REGENT trial—the end of cell therapy for MI?

Unselected bone-marrow-derived mononuclear cells seem to improve left ventricular function and perhaps short-term clinical outcomes for patients with acute myocardial infarction. The REGENT trial aimed to elucidate whether infusion of selected hematopoetic progenitor cells increases this effect in patients with large infarcts and attenuated left ventricular ejection fraction.

Rasmus S. Ripa
Jens Kastrup
News & Views01 Sept 2009
Nature Reviews Cardiology

Volume: 6, P: 567-568
3D whole body preclinical micro-CT database of subcutaneous tumors in mice with annotations from 3 annotators

Malte Jensen
Andreas Clemmensen
Rasmus Sejersten Ripa
ResearchOpen Access19 Sept 2024
Scientific Data

Volume: 11, P: 1-8
ABCB1 expression is increased in human first trimester placenta from pregnant women classified as overweight or obese

Signe Justesen
Katrine Bilde
Agnete Larsen
ResearchOpen Access30 Mar 2023
Scientific Reports

Volume: 13, P: 1-10
Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

Morten Orebo Holmström
Rasmus Erik Johansson Mortensen
Mads Hald Andersen
Research06 Jan 2021
Cellular & Molecular Immunology

Volume: 18, P: 415-426
Effect of liraglutide on expression of inflammatory genes in type 2 diabetes

Emilie H. Zobel
Rasmus S. Ripa
Joachim Størling
ResearchOpen Access17 Sept 2021
Scientific Reports

Volume: 11, P: 1-8

Search

Tolerability and effect of inhibiting microfibrillar-associated protein 4 in small intestinal anastomotic healing

Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease

STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor

Importance of an N-terminal structural switch in the distinction between small RNA-bound and free ARGONAUTE

Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk

In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes

Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

TMEFF1 is a neuron-specific restriction factor for herpes simplex virus

MYC activity at enhancers drives prognostic transcriptional programs through an epigenetic switch

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

STEEP mediates STING ER exit and activation of signaling

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

De novo mutations in familial adenomatous polyposis (FAP)

SAM68 directs STING signaling to apoptosis in macrophages

REGENT trial—the end of cell therapy for MI?

3D whole body preclinical micro-CT database of subcutaneous tumors in mice with annotations from 3 annotators

ABCB1 expression is increased in human first trimester placenta from pregnant women classified as overweight or obese

Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

Effect of liraglutide on expression of inflammatory genes in type 2 diabetes

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