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Showing 1–10 of 10 results
Advanced filters: Author: Ravi K. Lokareddy Clear advanced filters

  • Lokareddy et al. determine the complete structure of DEV, a lytic virus that infects Pseudomonas aeruginosa, using a combination of cryo-electron microscopy, biochemical methods, and genetic knockouts. They propose that the virion-associated RNA polymerase may be part of a genome ejection motor.

    • Ravi K. Lokareddy
    • Chun-Feng David Hou
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Importin β, the prototypical eukaryotic nuclear import receptor, transports a wide variety of cargos into the nucleus. Ko et al. used cryogenic electron microscopy to reveal an unexpected allosteric regulation of Importin β’s affinity for FG-nucleoporins, triggered by Ran-GTP.

    • Ying-Hui Ko
    • Fenglin Li
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Tailed bacteriophages assemble empty precursor capsids known as procapsids that are subsequently filled with viral DNA by a genome-packaging motor. Here the authors present a structure-based analysis that suggests the signal for termination of genome packaging is achieved through a DNA-dependent symmetrization of portal protein.

    • Ravi K. Lokareddy
    • Rajeshwer S. Sankhala
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Chlamydia trachomatis forms membrane-bound inclusions inside the host cell that are decorated with IncA, a SNARE-like protein that promotes the fusion of inclusions. Here, Cingolani et al. show that the protein folds into a non-canonical four-helix bundle and identify an intramolecular clamp required for membrane fusion.

    • Gino Cingolani
    • Michael McCauley
    • Fabienne Paumet
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. Here, the authors identify a bipartite Nuclear Localization Signal in the NF-κB p50/p65 heterodimer that is recognized with high affinity by importin α3.

    • Tyler J. Florio
    • Ravi K. Lokareddy
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • E217 is a Myoviridae used in an experimental phage cocktail to eradicate Pseudomonas aeruginosa. Here, the authors utilize cryo-EM and functional analysis to delineate E217 structural proteins, tail dynamics, and mechanisms of host recognition.

    • Fenglin Li
    • Chun-Feng David Hou
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.

    • Rajeshwer S. Sankhala
    • Ravi K. Lokareddy
    • Gino Cingolani
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • The Mycobacterium tuberculosis necrotizing toxin (TNT) is shown to cause toxicity by hydrolyzing NAD+ in the host cell. The crystal structure of TNT bound to its immunity factor reveals a new NAD+ glycohydrolase fold.

    • Jim Sun
    • Axel Siroy
    • Michael Niederweis
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 672-678