In the endoplasmic reticulum (ER), networks of protein homeostasis—proteostasis—regulate protein synthesis, folding and degradation via the unfolded protein response (UPR) pathway. A defective UPR is deleterious to renal cell function and viability and is implicated in the pathophysiology of various kidney pathologies. Here, the authors discuss the role of oxidative, glycative and hypoxic stress and how optimizing ER proteostasis might prevent and treat kidney diseases.
- Reiko Inagi
- Yu Ishimoto
- Masaomi Nangaku
