Nature Search

Cryo-EM structure of the RNA-guided ribonuclease Cas12g

The cryo-EM structures of Cas12g in complex with sgRNA in the absence and presence of target RNA reveal that the duplex formed by target RNA and crRNA binds to a central channel of Cas12g, inducing its conformational change and activation.

Zhuang Li
Heng Zhang
Leifu Chang
Research25 Jan 2021
Nature Chemical Biology

Volume: 17, P: 387-393
Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease

Cryo-EM structures of Cas12i in multiple functional states provide insights that might facilitate the manipulation of this type V CRISPR-Cas endonuclease for genome editing applications.

Heng Zhang
Zhuang Li
Leifu Chang
Research07 Sept 2020
Nature Structural & Molecular Biology

Volume: 27, P: 1069-1076
Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis

Brush-like biopolymers mimicking the lubrication properties of natural cartilage-binding complexes in articular joints enhance cartilage regeneration in a rat model of early osteoarthritis.

Renjian Xie
Hang Yao
Chuanbin Mao
Research04 Oct 2021
Nature Biomedical Engineering

Volume: 5, P: 1189-1201
Projected increase in carbon dioxide drawdown and acidification in large estuaries under climate change

Large eutrophic estuaries with long flushing times may become a greater carbon sink and acidify, while small estuaries with short flushing times are likely to remain a source of carbon to the atmosphere, according to coupled hydrodynamic-biogeochemical model and generalized box model simulations.

Ming Li
Yijun Guo
Jianzhong Su
ResearchOpen Access13 Mar 2023
Communications Earth & Environment

Volume: 4, P: 1-10
Investigation of the effect of relative humidity on micro lime consolidation of degraded earthen structures

Renjian Zeng
Gesa Schwantes
ResearchOpen Access31 Jul 2024
Heritage Science

Volume: 12, P: 1-18
Deep learning enhanced light sheet fluorescence microscopy for in vivo 4D imaging of zebrafish heart beating

The CNN-Transformer parallel network UI-Trans enables high-quality light sheet zebrafish heartbeat imaging, with ultra-economical acquisitions in terms of light dosage and acquisition time.

Meng Zhang
Renjian Li
Lingling Chen
ResearchOpen Access25 Feb 2025
Light: Science & Applications

Volume: 14, P: 1-14
ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs

Pengcheng Wang
Lixiao Zhang
Geng Wang
Research29 May 2024
Cell Research

Volume: 34, P: 504-521
Glucose-albumin ratio (GAR) as a novel biomarker for predicting postoperative pneumonia (POP) in older adults with hip fractures

Wanyun Tang
Xiaomin Ni
Renjian He
ResearchOpen Access04 Nov 2024
Scientific Reports

Volume: 14, P: 1-11
Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis

Kui Zhang
Gang Fu
Hongjuan Cui
ResearchOpen Access10 Oct 2018
Cell Death & Disease

Volume: 9, P: 1-14
Intrinsic hydroquinone-functionalized aggregation-induced emission core shows redox and pH sensitivity

Aggregation-induced emission (AIE) is exploited for several optoelectronic applications, but synthesizing molecules that respond to multiple stimuli is challenging. Here, the authors report a hydroquinone bearing an AIE-active core that responds to both redox and pH changes.

Mengshi Wang
Yuanheng Wang
Yen Wei
ResearchOpen Access23 Apr 2021
Communications Chemistry

Volume: 4, P: 1-9
Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment

Qingbin Zhang
Li Chen
Jian Ren
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-12
GPS-Lipid: a robust tool for the prediction of multiple lipid modification sites

Yubin Xie
Yueyuan Zheng
Jian Ren
ResearchOpen Access16 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
Cryo-EM structure of a type I-F CRISPR RNA guided surveillance complex bound to transposition protein TniQ

Zhuang Li
Heng Zhang
Leifu Chang
Correspondence03 Jan 2020
Cell Research

Volume: 30, P: 179-181

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