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Showing 1–2 of 2 results
Advanced filters: Author: Riccardo Vernuccio Clear advanced filters

  • The recent global mpox outbreaks underscore the critical need for antiviral development, hindered by the complexity of the MPXV genome. Using yeast TAR cloning, CRISPR-Cas9, and Lambda Red recombination to engineer replication-defective MPXV, the authors offer a platform for therapeutic research and identify G243-1720, a compound with a tecovirimat-like mechanism, as a promising anti-poxvirus compound.

    • Jiannan Chen
    • Liyuan Hu
    • Rong Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • Tecovirimat forces dimerization of the poxvirus phospholipase F13 blocking virus spread. Clinical monkeypox virus strains resistant to tecovirimat show mutations in the F13 dimer interface.

    • Riccardo Vernuccio
    • Alejandro Martínez León
    • Pablo Guardado-Calvo
    ResearchOpen Access
    Nature Microbiology
    Volume: 10, P: 734-748