Nature Search

Nature’s 10: ten people who helped shape science in 2021

An Omicron investigator, a Mars explorer and an AI ethics pioneer are some of the people behind the year’s big research stories.

Ewen Callaway
Holly Else
Richard Van Noorden
News15 Dec 2021
Nature

Volume: 600, P: 591-604
Structure of TANDEM and its implication for bifunctional intercalation into DNA

M. A. Viswamitra
Olga Kennard
Richard K. Olsen
Research26 Feb 1981
Nature

Volume: 289, P: 817-819
Importance of Membranes in Protein Biosynthesis

RICHARD W. HENDLER
Research01 Sept 1965
Nature

Volume: 207, P: 1053-1054
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
How birds are used to monitor pollution

Swallows and homing pigeons do their part for environmental surveillance.

Richard A. Lovett
News19 Nov 2012
Nature
A Semi-quantitative Method of Counting Nematode-trapping Fungi in Soil

HOWARD W. KLEMMER
RICHARD Y. NAKANO
Research05 Sept 1964
Nature

Volume: 203, P: 1085
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Flying into history

Richard Mabey
Books & Arts01 Nov 1988
Nature

Volume: 336, P: 273
A missing link in the transformation from asymmetric to symmetric metallofullerene cages implies a top-down fullerene formation mechanism

An asymmetric pentalene-containing C₁(51383)-C₈₄ fullerene cage is found in two different metal carbide metallofullerenes. This particular cage can, in simple steps, rearrange into many well-known fullerene cages that are more stable and more symmetric, suggesting it is likely that metallofullerenes are generated by a ‘top-down’ formation mechanism.

Jianyuan Zhang
Faye L. Bowles
Harry C. Dorn
Research15 Sept 2013
Nature Chemistry

Volume: 5, P: 880-885
Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

Ming Y. Cheng
F.-Ulrich Hartl
Arthur L. Horwich
Research16 Feb 1989
Nature

Volume: 337, P: 620-625
Green and pleasant

Richard Mabey
Books & Arts13 Dec 1984
Nature

Volume: 312, P: 674
A potent cyclic hexapeptide analogue of somatostatin

Daniel F. Veber
Roger M. Freidinger
Ralph Hirschmann
Research02 Jul 1981
Nature

Volume: 292, P: 55-58
Intrinsic density-dependent regulation of vole populations

Richard S. Ostffeld
Charles D. Canham
Stephen R. Pugh
Research18 Nov 1993
Nature

Volume: 366, P: 259-261
The Carnatic Rainfall

RICHARD STRACHEY
Research21 Jul 1887
Nature

Volume: 36, P: 267-268
Patterns of mortality and age at first reproduction in natural populations of mammals

Paul H. Harvey
Richard M. Zammuto
Research23 May 1985
Nature

Volume: 315, P: 319-320
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Multiple targeted grassland restoration interventions enhance ecosystem service multifunctionality

Widespread grassland degradation poses major societal and environmental challenges. Here, the authors propose multiple targeted interventions as a crucial strategy for simultaneously enhancing grassland ecosystem services and improving their equitability.

Shangshi Liu
Susan E. Ward
Richard D. Bardgett
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR

Robert E. Oswald
Michael J. Bogusky
Christopher M. Dobson
Research09 Feb 1989
Nature

Volume: 337, P: 579-582
Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation

Latchezar D. Todorov
Svetlana Mihaylova-Todorova
David P. Westfall
Research01 May 1997
Nature

Volume: 387, P: 76-79
Shedding light

Richard J. Griffiths
Books & Arts05 Jun 1975
Nature

Volume: 255, P: 514
Climate leadership in question as IPCC chief resigns

Chairman Rajendra Pachauri stands down amid allegations of sexual harassment.

Richard Van Noorden
Jeff Tollefson
Quirin Schiermeier
News24 Feb 2015
Nature
78,000-year-old record of Middle and Later Stone Age innovation in an East African tropical forest

Most of the archaeological record of the Middle to Later Stone Age transition comes from southern Africa. Here, Shipton et al. describe the new site Panga ya Saidi on the coast of Kenya that covers the last 78,000 years and shows gradual cultural and technological change in the Late Pleistocene.

Ceri Shipton
Patrick Roberts
Nicole Boivin
ResearchOpen Access09 May 2018
Nature Communications

Volume: 9, P: 1-8
Palaeogenomic analysis of black rat (Rattus rattus) reveals multiple European introductions associated with human economic history

‘Archaeogenetic analysis of black rat remains reveals that this species was introduced into temperate Europe twice, in the Roman and medieval periods. This population turnover was likely associated with multiple historical and environmental factors.’

He Yu
Alexandra Jamieson
David Orton
ResearchOpen Access03 May 2022
Nature Communications

Volume: 13, P: 1-13
The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar

Tick chitobiose is co-opted to build the cell wall of Lyme disease pathogen Borrelia burgdorferi.

Tanner G. DeHart
Mara R. Kushelman
Brandon L. Jutras
ResearchOpen Access24 Nov 2021
Nature Microbiology

Volume: 6, P: 1583-1592
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Perry L. McCarty 1931–2023

Perry L. McCarty, a pioneer in environmental biotechnology, passed away at the age of 91. His contributions to environmental engineering will live on.

Craig S. Criddle
Richard G. Luthy
Chungheon Shin
Comments & Opinion10 Jul 2023
Nature Sustainability

Volume: 6, P: 1033-1034
Rectosigmoidal manifestations of venous malformations: MR imaging findings and interdisciplinary therapeutic modalities

Richard Brill
Eva Brill
Walter A. Wohlgemuth
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-8
Anthropocene: The human age

Momentum is building to establish a new geological epoch that recognizes humanity's impact on the planet. But there is fierce debate behind the scenes.

Richard Monastersky
News11 Mar 2015
Nature

Volume: 519, P: 144-147
Publisher Correction: 78,000-year-old record of Middle and Later Stone Age innovation in an East African tropical forest

Ceri Shipton
Patrick Roberts
Nicole Boivin
Amendments and CorrectionsOpen Access05 Jun 2018
Nature Communications

Volume: 9, P: 1-2
Tale of a stigma redeemed

Richard Davenport-Hines
Books & Arts18 Mar 1999
Nature

Volume: 398, P: 209-210
Deep-sea research: Dive master

The US flagship submersible Alvin is getting a partial upgrade. But deep-sea exploration faces some rough water.

Richard Monastersky
News12 Sept 2012
Nature

Volume: 489, P: 194-196
GONADOTKOP IN SURGE IN INFANTS OF MEN WITH KALLMANN'S SYNDROME

Susan R Rose
Fernando Cassorla
Richard J Sherins
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 253
Global hotspots of species richness are not congruent with endemism or threat

C. David L. Orme
Richard G. Davies
Ian P. F. Owens
Research18 Aug 2005
Nature

Volume: 436, P: 1016-1019
Mass balance of the Greenland Ice Sheet from 1992 to 2018

Three techniques for estimating mass losses from the Greenland Ice Sheet produce comparable results for the period 1992–2018 that approach the trajectory of the highest rates of sea-level rise projected by the IPCC.

Andrew Shepherd
Erik Ivins
Jan Wuite
Research10 Dec 2019
Nature

Volume: 579, P: 233-239
Mass balance of the Antarctic Ice Sheet from 1992 to 2017

Andrew Shepherd
Erik Ivins
Bert Wouters
Research13 Jun 2018
Nature

Volume: 558, P: 219-222
UYSD: a novel data repository accessible via public website for worldwide population frequencies of Y-SNP haplogroups

Arwin Ralf
Dion Zandstra
Manfred Kayser
ResearchOpen Access08 May 2025
European Journal of Human Genetics

Volume: 33, P: 904-912
A New Pleistocene Hominin Tracksite from the Cape South Coast, South Africa

Charles W. Helm
Richard T. McCrea
Sinèad Hattingh
ResearchOpen Access28 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
Heart in space: effect of the extraterrestrial environment on the cardiovascular system

The effects of microgravity and cosmic rays on the cardiovascular system are major health concerns for astronauts in space. In this Review, Hughson and colleagues summarize the current evidence on risk estimation and dysfunction of the cardiovascular system in space, and discuss potential countermeasures, including physical exercise, antioxidants, nutraceuticals, and radiation shielding.

Richard L. Hughson
Alexander Helm
Marco Durante
Reviews20 Oct 2017
Nature Reviews Cardiology

Volume: 15, P: 167-180
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines

This work provides a first molecular view of dendritic spines, for both the mushroom and stubby classes, obtained by integrating electron microscopy, quantitative biochemistry, super-resolution microscopy and 3D molecular visualizations.

Martin S. Helm
Tal M. Dankovich
Silvio O. Rizzoli
Research24 Jun 2021
Nature Neuroscience

Volume: 24, P: 1151-1162
Unexpected diversity in socially synchronized rhythms of shorebirds

Socially synchronized rhythms in shorebirds were assessed during biparental incubation under natural circumstances and were exceptionally diverse, often not following the 24-h day, whereby risk of predation, not starvation, determined some of the variation in incubation rhythms.

Martin Bulla
Mihai Valcu
Bart Kempenaers
Research23 Nov 2016
Nature

Volume: 540, P: 109-113
Antiskyrmions and their electrical footprint in crystalline mesoscale structures of Mn_1.4PtSn

Topological spin textures are promising for their potential application in racetrack memory devices. Here, the characteristic Hall transport signature of antiskyrmions is investigated in Mn_1.4PtSn, providing a platform for higher magnetic and temperature tunability over traditional skyrmion compounds.

Moritz Winter
Francisco J. T. Goncalves
Toni Helm
ResearchOpen Access20 Dec 2022
Communications Materials

Volume: 3, P: 1-9
Life history variation associated with the polymorphism for capitulum type and outcrossing rate in Senecio vulgaris L.

Richard J Abbott
Research01 Jun 1986
Heredity

Volume: 56, P: 381-391
Proteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala

Kayla Farrell
Madeline Musaus
Timothy J. Jarome
Research17 May 2023
Molecular Psychiatry

Volume: 28, P: 2594-2605
A call for direct sequencing of full-length RNAs to identify all modifications

For most organisms, DNA sequences are available, but the complete RNA sequences are not. Here, we call for technologies to sequence full-length RNAs with all their modifications.

Juan D. Alfonzo
Jessica A. Brown
Robert L. Ross
Comments & Opinion15 Jul 2021
Nature Genetics

Volume: 53, P: 1113-1116
Author Correction: Rectosigmoidal manifestations of venous malformations: MR imaging findings and interdisciplinary therapeutic modalities

Richard Brill
Eva Brill
Walter A. Wohlgemuth
Amendments and CorrectionsOpen Access07 Feb 2020
Scientific Reports

Volume: 10, P: 1
Functional annotation of serine hydrolases in the asexual erythrocytic stage of Plasmodium falciparum

Rubayet Elahi
W. Keith Ray
Michael Klemba
ResearchOpen Access26 Nov 2019
Scientific Reports

Volume: 9, P: 1-11
MR imaging of venous malformations: sciatic nerve infiltration patterns and involved muscle groups

Constantin Goldann
Maximilian Helm
Richard Brill
ResearchOpen Access03 Sept 2020
Scientific Reports

Volume: 10, P: 1-10
The dynamic response of the Arabidopsis root metabolome to auxin and ethylene is not predicted by changes in the transcriptome

Sherry B. Hildreth
Evan E. Foley
Brenda S. J. Winkel
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-15
Fasting differentially alters the hypothalamic proteome of chickens from lines with the propensity to be anorexic or obese

Lingbin Liu
Jiaqing Yi
Elizabeth R. Gilbert
ResearchOpen Access01 Apr 2019
Nutrition & Diabetes

Volume: 9, P: 1-13

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