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Showing 1–3 of 3 results
Advanced filters: Author: Rico J. E. Derks Clear advanced filters
  • Ex vivo normothermic machine perfusion has been proposed to protect donor kidneys. Here, the authors show that red blood cell-based human kidney perfusion and associated hemolysis contribute to iron accumulation, ferroptosis, and kidney injury.

    • Marlon J. A. de Haan
    • Marleen E. Jacobs
    • Ton J. Rabelink
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • The authors introduce the Neurolipid Atlas, a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease, and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease.

    • Femke M. Feringa
    • Sascha J. Koppes-den Hertog
    • Rik van der Kant
    ResearchOpen Access
    Nature Metabolism
    Volume: 7, P: 2142-2164
  • After activation, conventional T cells undergo metabolic reprogramming. de Kivit et al. show that in human thymic regulatory T cells, TNFR2 stimulation promotes a glycolytic switch with a preferential glucose-derived carbon flux into the TCA cycle to support suppressive functions.

    • Sander de Kivit
    • Mark Mensink
    • Jannie Borst
    Research
    Nature Metabolism
    Volume: 2, P: 1046-1061