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Tissue-resident exhausted and memory CD8⁺ T cells have distinct ontogeny, function and roles in disease

Here the authors show that persistent antigen stimulation drives the generation of CD8⁺ tissue-resident exhausted T cells with distinct developmental origins, function and therapeutic responsiveness when compared to CD8⁺ tissue-resident memory T cells.

Simone L. Park
Mark M. Painter
E. John Wherry
Research29 Dec 2025
Nature Immunology

Volume: 27, P: 110-125
Publisher Correction: Tissue-resident exhausted and memory CD8⁺ T cells have distinct ontogeny, function and roles in disease

Simone L. Park
Mark M. Painter
E. John Wherry
Amendments and Corrections13 Jan 2026
Nature Immunology

Volume: 27, P: 378
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy

SARS-CoV-2-specific antibodies and memory B cells are significantly reduced, but CD4⁺ and CD8⁺ T cells are robustly activated, in patients with multiple sclerosis on anti-CD20 monotherapy versus healthy controls after BNT162b2 or mRNA-1273 mRNA vaccination.

Sokratis A. Apostolidis
Mihir Kakara
Amit Bar-Or
ResearchOpen Access14 Sept 2021
Nature Medicine

Volume: 27, P: 1990-2001
Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

Wherry and colleagues define the kinetics of vaccine-primed recall immune responses during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection, highlighting rapid activation of memory T cells and broadly enhanced immune responses in previously vaccinated individuals.

Mark M. Painter
Timothy S. Johnston
E. John Wherry
Research21 Sept 2023
Nature Immunology

Volume: 24, P: 1711-1724
Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus

Increased risk of premature cardiovascular disease in systemic lupus erythematosus (SLE) is not well understood, but in animal models, the Janus kinase inhibitor tofacitinib improves related phenotypes. Here the authors report a Phase 1 double-blind randomized trial that shows tofacitinib is safe and well tolerated in in patients with SLE.

Sarfaraz A. Hasni
Sarthak Gupta
Mariana J. Kaplan
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-11
Shared and distinct biological circuits in effector, memory and exhausted CD8⁺ T cells revealed by temporal single-cell transcriptomics and epigenetics

Wherry and colleagues provide a comparative analysis of paired single-cell RNA-sequencing and single-cell assay for transposase-accessible chromatin sequencing profiles of CD8⁺ T cells in acute and chronic lymphocytic choriomeningitis virus infections, identifying new features about T_ex cell subsets and epigenetic differences from acutely infected precursors seen at early time points in infection.

Josephine R. Giles
Shin Foong Ngiow
E. John Wherry
Research21 Oct 2022
Nature Immunology

Volume: 23, P: 1600-1613
Interferon lambda in inflammation and autoimmune rheumatic diseases

Type III interferons (IFNλs) affect innate and adaptive immune responses and are associated with the pathogenesis of autoimmune rheumatic diseases. In this Review, the authors provide an overview of IFNλs in rheumatic diseases and discuss therapeutic strategies to target them.

Rishi R. Goel
Sergei V. Kotenko
Mariana J. Kaplan
Reviews27 Apr 2021
Nature Reviews Rheumatology

Volume: 17, P: 349-362
30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Rishi Singhal
Victor Roth Cardoso
Mehmet Saydam
ResearchOpen Access15 Dec 2021
International Journal of Obesity

Volume: 46, P: 750-757

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