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Showing 1–6 of 6 results
Advanced filters: Author: Rob Verhagen Clear advanced filters

  • The dense desmoplastic stroma and insufficient infiltrating T cells limit effective immunotherapy in pancreatic ductal adenocarcinoma (PDAC). The authors here administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-specific antibody (mitazalimab) to patients with metastatic PDAC after (m)FOLFIRINOX standard-of-care treatment and find MesoPher/mitazalimab combination therapy is safe and tolerable, accompanied with enhanced systemic and local immune responses.

    • Songul Kucukcelebi
    • Freek R. van ‘t Land
    • Casper H. J. van Eijck
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Foamy macrophages are a pathological hallmark of demyelinating brain disorders. Here, the authors identify the molecular mechanisms underlying the faulty regulation of lipid efflux that cause accumulation, suggesting a promising strategy to enhance central nervous system repair.

    • Melanie Loix
    • Sam Vanherle
    • Jeroen F. J. Bogie
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Fully integratable spectrometers have trade-offs between size and resolution. Here, the authors present a nano-opto-electro-mechanical system where the functionalities of transduction, actuation and detection are fully integrated, resulting in an ultra-compact high-resolution spectrometer with a micrometer-scale footprint.

    • Žarko Zobenica
    • Rob W. van der Heijden
    • Andrea Fiore
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Aida Bertoli-Avella and colleagues report the identification of SMAD3 mutations in individuals with a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis. The mutations cause increased aortic expression of components of the TGF-β signaling pathway.

    • Ingrid M B H van de Laar
    • Rogier A Oldenburg
    • Aida M Bertoli-Avella
    Research
    Nature Genetics
    Volume: 43, P: 121-126

  • Although never demonstrated in humans, exchange of the antigen-binding regions of IgG4 antibodies with different specificities could complicate certain antibody therapies. Labrijn et al. show that Fab-arm exchange occurs in patients and propose that a single mutation can inhibit the process.

    • Aran F Labrijn
    • Antonio Ortiz Buijsse
    • Paul W H I Parren
    Research
    Nature Biotechnology
    Volume: 27, P: 767-771