Nature Search

Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia

It is not well understood why in resource-poor settings some children fail to gain weight and stunting increases following hospital discharge. Here, the authors show inflammation driven by illness, enteropathy and social factors redirects recovery away from linear growth and limits weight gain.

James M. Njunge
Evans O. Mudibo
James A. Berkley
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-14
Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries

Childhood mortality is a global health problem. Plasma lipopolysaccharide levels, inflammatory stool biomarkers and proteomics were used in a nested case-cohort in sub-Saharan Africa and South Asia to predict mortality and decode immune mechanisms.

Chris A. D. Allen
Arya Ghate
Holm H. Uhlig
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Intestinal disturbances associated with mortality of children with complicated severe malnutrition

Wen et al. investigate associations between intestinal disturbances and mortality in children hospitalized with complicated severe malnutrition. Differences are seen in the fecal metabolome of children who die compared with those who are discharged, with integrative analyses suggesting an indirect role for intestinal inflammation in mortality.

Bijun Wen
Amber Farooqui
Robert H. J. Bandsma
ResearchOpen Access29 Sept 2023
Communications Medicine

Volume: 3, P: 1-10
The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction

Impaired liver metabolic function is related to mortality in severely malnourished children. Here the authors report a role for the tryptophan-NAD + pathway in reduced hepatic mitochondrial function and liver steatosis in a mouse model of severe malnutrition.

Guanlan Hu
Catriona Ling
Robert H. J. Bandsma
ResearchOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1-16
Upregulated pexophagy limits the capacity of selective autophagy

An accumulation of one substrate of selective autophagy can lead to autophagic degradation deficiencies. Here, the authors show that a pathogenic increase in a single autophagy pathway restricts another by consuming the cell’s autophagy capacity.

Kyla Germain
Raphaella W. L. So
Peter K. Kim
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-18
Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV

Here the authors show in a case-control study with more than 800 children that HIV indirectly affects early post-discharge growth in children recovering from severe malnutrition by impacting baseline anthropometry and altering proteins key to bone mineralisation, growth signalling, and humoral immune response.

Evans O. Mudibo
Jasper Bogaert
Gerard Bryan Gonzales
ResearchOpen Access27 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition

Mohamed Karim Maghraby
Bo Li
Robert H. J. Bandsma
ResearchOpen Access07 Apr 2021
Scientific Reports

Volume: 11, P: 1-14
Cholesterol Synthesis and De Novo Lipogenesis in Premature Infants Determined by Mass Isotopomer Distribution Analysis

Lorraine N Renfurm
Robert H J Bandsma
Pieter J J Sauer
Research01 Oct 2004
Pediatric Research

Volume: 56, P: 602-607
Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut

Micronutrient supplements are key to global efforts to address child malnutrition. Here, in a cohort of children, previously enrolled into a large cluster randomized controlled trial of micronutrient supplementation in Pakistan, Popovic et al. find that vitamins and iron increase carriage of protozoa and fungi in the gut, potentially disrupting the bacterial microbiome.

Ana Popovic
Celine Bourdon
Lisa G. Pell
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-13
Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition: a longitudinal study

Farzana Afroze
Farnaz Khoshnevisan
Robert H. J. Bandsma
ResearchOpen Access13 Feb 2024
Scientific Reports

Volume: 14, P: 1-13
Inhibition of mTOR improves malnutrition induced hepatic metabolic dysfunction

Matilda E. Arvidsson Kvissberg
Guanlan Hu
Robert Bandsma
ResearchOpen Access19 Nov 2022
Scientific Reports

Volume: 12, P: 1-12
A novel shape-based approach to identify gestational age-adjusted growth patterns from birth to 11 years of age

Lorena López-Domínguez
Diego G. Bassani
Robert H. J. Bandsma
ResearchOpen Access31 Jan 2023
Scientific Reports

Volume: 13, P: 1-10
Increased de novo Lipogenesis and Delayed Conversion of Large VLDL into Intermediate Density Lipoprotein Particles Contribute to Hyperlipidemia in Glycogen Storage Disease Type 1a

Robert H J Bandsma
Berthil H Prinsen
Folkert Kuipers
Research01 Jun 2008
Pediatric Research

Volume: 63, P: 702-707
Mechanisms Behind Decreased Endogenous Glucose Production in Malnourished Children

Robert H J Bandsma
Marijke Mendel
Geert Tom Heikens
Research01 Nov 2010
Pediatric Research

Volume: 68, P: 423-428
Severe childhood malnutrition

Children with severe malnutrition (which includes severe wasting and kwashiorkor) have an elevated risk of serious illness and death, primarily from acute infectious diseases. In this Primer, the authors describe the multifactorial aetiology of severe malnutrition and the efforts needed to meet the United Nations’ Sustainable Development Goal of zero hunger.

Zulfiqar A. Bhutta
James A. Berkley
André Briend
Reviews21 Sept 2017
Nature Reviews Disease Primers

Volume: 3, P: 1-18
Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition

Gerard Bryan Gonzales
James M. Njunge
James A. Berkley
ResearchOpen Access08 Jul 2020
Scientific Reports

Volume: 10, P: 1-11
Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi

Rosalie H. Bartels
Emmanuel Chimwezi
Stephen J. Allen
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis: proof of concept

Deborah A. van den Brink
Tim de Meij
Wieger P. Voskuijl
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition

James M. Njunge
Agnes Gwela
James A. Berkley
ResearchOpen Access12 Apr 2019
Scientific Reports

Volume: 9, P: 1-12
The relationship between fecal bile acids and microbiome community structure in pediatric Crohn’s disease

Jessica Connors
Katherine A Dunn
Johan Van Limbergen
Research03 Dec 2019
The ISME Journal

Volume: 14, P: 702-713
Author Correction: Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis: proof of concept

Deborah A. van den Brink
Tim de Meij
Wieger P. Voskuijl
Amendments and CorrectionsOpen Access03 Feb 2021
Scientific Reports

Volume: 11, P: 1

Search

Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia

Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries

Intestinal disturbances associated with mortality of children with complicated severe malnutrition

The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction

Upregulated pexophagy limits the capacity of selective autophagy

Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV

Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition

Cholesterol Synthesis and De Novo Lipogenesis in Premature Infants Determined by Mass Isotopomer Distribution Analysis

Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut

Trajectories of resting energy expenditure and performance of predictive equations in children hospitalized with an acute illness and malnutrition: a longitudinal study

Inhibition of mTOR improves malnutrition induced hepatic metabolic dysfunction

A novel shape-based approach to identify gestational age-adjusted growth patterns from birth to 11 years of age

Increased de novo Lipogenesis and Delayed Conversion of Large VLDL into Intermediate Density Lipoprotein Particles Contribute to Hyperlipidemia in Glycogen Storage Disease Type 1a

Mechanisms Behind Decreased Endogenous Glucose Production in Malnourished Children

Severe childhood malnutrition

Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition

Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi

Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis: proof of concept

Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition

The relationship between fecal bile acids and microbiome community structure in pediatric Crohn’s disease

Author Correction: Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis: proof of concept

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