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Showing 1–12 of 12 results
Advanced filters: Author: Robert M. Brosh Jr Clear advanced filters

  • The authors review the consequences of mutations in genes linked to rare hereditary disorders associated with G-quadruplex (G4)-induced replisome stalling, as well as the molecular functions and cellular pathways of these G4-interacting proteins.

    • Lauren M. Herr
    • Swagata Mukhopadhyay
    • Martina Rossi
    ReviewsOpen Access
    Communications Biology
    Volume: 9, P: 1-24

  • Resolution of G4s has been suggested to be required for efficient DNA replication. Here, the authors show that the nuclease DNA2 and the DNA repair complex MutSα (MSH2-MSH6) are required to remove G4 stabilized by environmental compounds to allow efficient telomere replication.

    • Anthony Fernandez
    • Tingting Zhou
    • Binghui Shen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • In cells with microsatellite instability, expanded TA-dinucleotide repeats form cruciform structures that stall replication forks and cause chromosome shattering in the absence of the WRN helicase.

    • Niek van Wietmarschen
    • Sriram Sridharan
    • André Nussenzweig
    Research
    Nature
    Volume: 586, P: 292-298

  • Here the authors show that the DNA helicase WRN ‘s interaction with the single stranded DNA binding protein RPA is regulated through specific phosphorylation by Casein Kinase 2. This regulation is critical for resolving DNA replication stress caused by G-quadruplexes.

    • Alessandro Noto
    • Pasquale Valenzisi
    • Pietro Pichierri
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • The tumor suppressor BRCA2 protects stalled DNA replication forks from unrestrained degradation; however the mechanism whereby unprotected stalled forks are preserved and restarted has remained elusive. Here the authors show that the WRN helicase promotes stalled fork recovery and limits fork hyper-degradation in the absence of BRCA2 protection.

    • Arindam Datta
    • Kajal Biswas
    • Robert M. Brosh Jr
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22

  • End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-related breaks.

    • Valentina Palermo
    • Sara Rinalducci
    • Pietro Pichierri
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • Genomic instability often underlies cancer. Analyses of proteins implicated in a cancer-predisposing condition called Bloom's syndrome illustrate the intricacies of protein interactions that ensure genomic stability.

    • Robert M. Brosh Jr
    News & Views
    Nature
    Volume: 456, P: 453-454

  • Several cancers and genetic disorders are linked to defects in helicases that have roles in genome maintenance and stability. This Review discusses helicase-dependent DNA repair pathways and how targeting these might improve cancer treatments based on DNA-damaging chemotherapy or radiation.

    • Robert M. Brosh Jr.
    Reviews
    Nature Reviews Cancer
    Volume: 13, P: 542-558

  • This review discusses recent advances demonstrating the role of replication stress as an ultimate driver of cellular senescence and aging, highlighting connections to hallmarks of aging, hereditary accelerated aging disorders, and senotherapeutics.

    • Lauren M. Herr
    • Ethan D. Schaffer
    • Robert M. Brosh Jr.
    ReviewsOpen Access
    Communications Biology
    Volume: 7, P: 1-19