By engaging innate immune receptors and inducing the production of proinflammatory cytokines, cells can sense and respond to danger signals. Defective regulation of these sensory and response mechanisms by indiscriminate recognition of self molecules or as a result of genetic mutation can result in autoimmune or autoinflammatory rheumatic diseases, as outlined in this Review.
- Argyrios N. Theofilopoulos
- Rosana Gonzalez-Quintial
- Roberto Baccala
