Mucida and colleagues developed Tracking Recently Activated Cell Kinetics (TRACK) mice, which allow spatial and temporal labeling of recently activated CD4⁺ T cells. Using these mice, they show that, during influenza infection, tissue-specific environments drive both divergent CD4⁺ T cell differentiation and clonal selection.
- Roham Parsa
- Helder C. Assis
- Daniel Mucida