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Showing 1–6 of 6 results
Advanced filters: Author: Roham Parsa Clear advanced filters
  • Mucida and colleagues developed Tracking Recently Activated Cell Kinetics (TRACK) mice, which allow spatial and temporal labeling of recently activated CD4⁺ T cells. Using these mice, they show that, during influenza infection, tissue-specific environments drive both divergent CD4⁺ T cell differentiation and clonal selection.

    • Roham Parsa
    • Helder C. Assis
    • Daniel Mucida
    Research
    Nature Immunology
    Volume: 27, P: 725-737
  • A paper reports the development of a universal tool for studying cellular interactions in biological systems, and demonstrates its coupling with single-cell transcriptomics methods to provide insights into the biology of the interactions.

    • Sandra Nakandakari-Higa
    • Sarah Walker
    • Gabriel D. Victora
    Research
    Nature
    Volume: 627, P: 399-406
  • Brain microglial cells can be replenished by blood-derived monocytes, but many aspects of this repopulation remain unclear. Here the authors show that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6Chi monocytes, with the latter having overlapping but distinct characteristics.

    • Harald Lund
    • Melanie Pieber
    • Robert A. Harris
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13
  • The cytokine IL-18 can drive autoantibody production. Karlsson and colleagues show that such responses are limited by a three-way cellular interaction whereby splenic neutrophils activate both B cells and invariant natural killer T cells but the activated B cells are killed by FasL+ invariant natural killer T cells.

    • Thomas Hägglöf
    • Saikiran K Sedimbi
    • Mikael C I Karlsson
    Research
    Nature Immunology
    Volume: 17, P: 1407-1414