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Showing 1–6 of 6 results
Advanced filters: Author: Ron Saad Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • This Review discusses recurrent aneuploidies driving human cancer, methods to identify them and strategies to uncover underlying driver genes. It highlights genomic and experimental approaches to study and ultimately target driver aneuploidies.

    • Eran Sdeor
    • Hajime Okada
    • Uri Ben-David
    Reviews
    Nature Genetics
    Volume: 56, P: 2014-2026

  • Marina Shenkman et al. show that the ERAD mannosidases EDEM1 and EDEM2 have bona fide mannosidase activity in vitro. The activity of these enzymes is substantially faster when their glycoprotein substrates are in the unfolded state, suggesting a mechanism for efficient ERAD targeting of unfolded or misfolded glycoproteins.

    • Marina Shenkman
    • Efrat Ron
    • Gerardo Z. Lederkremer
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-11

  • Emerging data suggest a role for autoimmunity in type 2 diabetes mellitus (T2DM). In this Perspectives, the authors discuss the nature of the immune response in diabetes mellitus and the evidence for an autoimmune component in T2DM and obesity.

    • Lício A. Velloso
    • Decio L. Eizirik
    • Miriam Cnop
    Reviews
    Nature Reviews Endocrinology
    Volume: 9, P: 750-755