Nature Search

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

Alexander Teumer
Yong Li
Anna Köttgen
ResearchOpen Access11 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Genetic loci influencing kidney function and chronic kidney disease

John Chambers and colleagues identify common variants at four loci associated with serum creatinine levels, a marker of kidney function. Their findings provide insight into the pathways underlying susceptibility to chronic kidney disease.

John C Chambers
Weihua Zhang
Jaspal S Kooner
Research11 Apr 2010
Nature Genetics

Volume: 42, P: 373-375
The senescence-inducing factor IGFBP7 and risk of atrial fibrillation: findings from the PREVEND study

Navin Suthahar
Ron T. Gansevoort
Rudolf A. de Boer
ResearchOpen Access12 Aug 2025
npj Cardiovascular Health

Volume: 2, P: 1-6
Correction: Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Helen R Warren
Evangelos Evangelou
Paul Elliott
Amendments and Corrections01 Oct 2017
Nature Genetics

Volume: 49, P: 1558
A catalog of genetic loci associated with kidney function from analyses of a million individuals

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

Matthias Wuttke
Yong Li
Cristian Pattaro
Research31 May 2019
Nature Genetics

Volume: 51, P: 957-972
Defining the role of common variation in the genomic and biological architecture of adult human height

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Andrew R Wood
Tonu Esko
Timothy M Frayling
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1173-1186
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension.

Helen R Warren
Evangelos Evangelou
Paul Elliott
Research30 Jan 2017
Nature Genetics

Volume: 49, P: 403-415
Genetic studies of body mass index yield new insights for obesity biology

A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

Adam E. Locke
Bratati Kahali
Elizabeth K. Speliotes
Research11 Feb 2015
Nature

Volume: 518, P: 197-206
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of European, East Asian and South Asian ancestry. They find trait-associated SNPs at 12 loci, some of which are associated with methylation at nearby CpG sites.

Norihiro Kato
Marie Loh
John C Chambers
Research21 Sept 2015
Nature Genetics

Volume: 47, P: 1282-1293
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci influencing this trait. Enrichment analyses, fine-mapping and colocalization with gene expression in 47 tissues implicate the kidney and liver as key target organs and prioritize potential causal genes.

Adrienne Tin
Jonathan Marten
Anna Köttgen
Research02 Oct 2019
Nature Genetics

Volume: 51, P: 1459-1474
CKD is a key risk factor for COVID-19 mortality

A new study uses the OpenSAFELY health analytics platform to identify risk factors for COVID-19 mortality. This analysis, which includes data for more than 17 million people in the UK, suggests that patients with chronic kidney disease are at higher risk than those with other known risk factors, including chronic heart and lung disease.

Ron T. Gansevoort
Luuk B. Hilbrands
News & Views26 Aug 2020
Nature Reviews Nephrology

Volume: 16, P: 705-706
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

A genome-wide association meta-analysis study here shows novel genetic loci to be associated to body fat percentage, and describes cross-phenotype association that further demonstrate a close relationship between adiposity and cardiovascular disease risk.

Yingchang Lu
Felix R. Day
Ruth J. F. Loos
ResearchOpen Access01 Feb 2016
Nature Communications

Volume: 7, P: 1-15
Albuminuria as a cause of hypertension

A genetic study using a Mendelian randomization approach provides evidence that albuminuria — as well as being the result of hypertension — might also cause hypertension and cardiometabolic disease. We suggest that a mechanism behind these findings could involve sodium retention by urinary protein-induced activation of the epithelial sodium channel in the distal tubule.

Ron T. Gansevoort
Harold Snieder
News & Views22 Oct 2018
Nature Reviews Nephrology

Volume: 15, P: 6-8
New genetic loci link adipose and insulin biology to body fat distribution

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Dmitry Shungin
Thomas W. Winkler
Karen L Mohlke
Research11 Feb 2015
Nature

Volume: 518, P: 187-196
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Past genome-wide associate studies have identified hundreds of genetic loci that influence body size and shape when examined one trait at a time. Here, Jeff and colleagues develop an aggregate score of various body traits, and use meta-analysis to find new loci linked to body shape.

Janina S. Ried
Janina Jeff M.
Ruth J. F. Loos
ResearchOpen Access23 Nov 2016
Nature Communications

Volume: 7, P: 1-11
The epidermal growth factor receptor pathway in chronic kidney diseases

Dysregulation of the epidermal growth factor receptor (EGFR) pathway has a role in numerous kidney diseases. This Review explores the function of the EGFR pathway in renal physiology and pathology and the clinical potential of targeting this signalling pathway as a therapeutic strategy to treat kidney diseases.

Laura R. Harskamp
Ron T. Gansevoort
Esther Meijer
Reviews04 Jul 2016
Nature Reviews Nephrology

Volume: 12, P: 496-506
Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.

Fumihiko Takeuchi
Masato Akiyama
Norihiro Kato
ResearchOpen Access28 Nov 2018
Nature Communications

Volume: 9, P: 1-16
Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

Yejin Mok
Aditya Surapaneni
Michael G. Shlipak
ResearchOpen Access06 Sept 2025
British Journal of Cancer

Volume: 133, P: 1535-1543
Informing clinical decision making during a pandemic — a call for better preparedness

The COVID-19 pandemic exposed flaws in the ability of the nephrology community to efficiently inform clinical decision making. To improve preparedness for the next pandemic, the nephrology community must work more closely together to ensure that research efforts are aligned and put in place a strategy for the effective dissemination of high-quality evidence in real-time.

Priya Vart
Luuk B. Hilbrands
Ron T. Gansevoort
Comments & Opinion18 Jan 2023
Nature Reviews Nephrology

Volume: 19, P: 149-150
Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients

Yvette den Hartog
S. Reshwan K. Malahe
Rob van Binnendijk
ResearchOpen Access14 Feb 2024
npj Viruses

Volume: 2, P: 1-10
Reducing the costs of chronic kidney disease while delivering quality health care: a call to action

The treatment of chronic kidney disease (CKD) and end-stage renal disease (ESRD) is associated with immense societal costs, with particularly high expenditure for renal replacement therapy. This Review addresses the economic aspects of CKD and ESRD with a focus on approaches to prevent the conditions that contribute to CKD and its progression.

Raymond Vanholder
Lieven Annemans
Carmine Zoccali
Reviews30 May 2017
Nature Reviews Nephrology

Volume: 13, P: 393-409
Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy

Priya Vart
Raphaël Duivenvoorden
Mahmud Islam
ResearchOpen Access26 Oct 2022
Scientific Reports

Volume: 12, P: 1-13
Th₁-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses

Yvette den Hartog
S. Reshwan K. Malahe
Carla C. Baan
ResearchOpen Access17 May 2023
npj Vaccines

Volume: 8, P: 1-10
Publisher Correction: Lower body mass index and mortality in older adults starting dialysis

Harmke A. Polinder-Bos
Merel van Diepen
Carlo A. J. M. Gaillard
Amendments and CorrectionsOpen Access18 Sept 2018
Scientific Reports

Volume: 8, P: 1
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.

Thomas W. Winkler
Humaira Rasheed
Iris M. Heid
ResearchOpen Access13 Jun 2022
Communications Biology

Volume: 5, P: 1-20
Erratum: Genome-wide association studies identify genetic loci for low von Willebrand factor levels

Janine van Loon
Abbas Dehghan
Christopher O'Donnell
Amendments and Corrections16 Jun 2016
European Journal of Human Genetics

Volume: 24, P: 1096
Genome-wide association studies identify genetic loci for low von Willebrand factor levels

Janine van Loon
Abbas Dehghan
Christopher O'Donnell
Research21 Oct 2015
European Journal of Human Genetics

Volume: 24, P: 1035-1040
Lower body mass index and mortality in older adults starting dialysis

Harmke A. Polinder-Bos
Merel van Diepen
Carlo A. J. M. Gaillard
ResearchOpen Access27 Aug 2018
Scientific Reports

Volume: 8, P: 1-9
Relative fat mass, a new index of adiposity, is strongly associated with incident heart failure: data from PREVEND

Navin Suthahar
Laura M. G. Meems
Rudolf A. de Boer
ResearchOpen Access07 Jan 2022
Scientific Reports

Volume: 12, P: 1-9

Search

Filter By:

Search

Quick links