Nature Search

Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome

Multi-omics and genetic models show that CGG repeat toxicity in GABAergic neurons drives FXTAS pathology and identify PRKCG as a critical modifier and potential therapeutic target.

Yulin Jin
Yiqu Cao
Peng Jin
ResearchOpen Access08 Jan 2026
Nature Communications

P: 1-19
Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma

Paraoxonase-1 (PON1) is a liver-specific glycoprotein that has been shown to be a tumor suppressor in hepatocellular carcinoma (HCC). Here, the authors show that PON1 reduces HCC tumor growth due to regulation of lactic acid production and regulatory T cell-mediated immunosuppression.

Zhou Lu
Huanchen Shi
Cheng Huang
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-15
Structure and evolution of the Himalaya–Tibet orogenic belt

C. J. Allégre
V. Courtillot
Ronghua Xu
Research05 Jan 1984
Nature

Volume: 307, P: 17-22
High-capacity, fast-charging and long-life magnesium/black phosphorous composite negative electrode for non-aqueous magnesium battery

Uneven Mg plating behaviour at the negative electrode leads to high plating overpotential and short cycle life. Here, to circumvent these issues, authors report the preparation of a magnesium/black phosphorus composite and its use as a negative electrode for non-aqueous magnesium-based batteries.

Qiannan Zhao
Kaiqi Zhao
Jong-Beom Baek
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Efficient GPT-4V level multimodal large language model for deployment on edge devices

Multimodal Large Language Models are energy intensive and computationally demanding. Here, the authors developed a series of lightweight Multimodal Large Language Models deployable on edge devices.

Yuan Yao
Tianyu Yu
Maosong Sun
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Million-year solar wind irradiation recorded in chang’E-5 and chang’E-6 samples

Chang’E-5 lunar soils show unusually fast growth of solar wind–damaged rims compared with Chang’E-6 and Apollo samples, potentially pointing to local conditions that enhance solar wind effects on the Moon.

Renrui Liu
Xiaoping Zhang
Chi Wang
ResearchOpen Access16 Oct 2025
Nature Communications

Volume: 16, P: 1-9
Robust performance optimization of UAV dynamic systems using MPC-PID hybrid control

Wei Zhou
Linzhen Zhou
Dakun Liu
ResearchOpen Access06 Jan 2026
Scientific Reports

Volume: 16, P: 1-15
Calculation of shield tunnel uplift induced by synchronous grouting

Ye Zhou
Ganbin Liu
Yao Ji
ResearchOpen Access14 Nov 2025
Scientific Reports

Volume: 15, P: 1-21
Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer

Zongming Dong
Xiaosa Chang
Ji Zheng
ResearchOpen Access24 May 2025
Scientific Reports

Volume: 15, P: 1-17
Exploitation of heterosis loci for yield and yield components in rice using chromosome segment substitution lines

Yajun Tao
Jinyan Zhu
Guohua Liang
ResearchOpen Access11 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Mobilizing antigen-presenting mast cells in anti-PD-1-refractory triple-negative breast cancer: a phase 2 trial

In a reverse-translational study followed by a clinical trial, the targeting of antigen-presenting mast cells was identified as a therapeutic approach to overcome anti-PD-1 resistance in patients with metastatic triple-negative breast cancer who experienced clinical benefit when treated with the mast cell stabilizer cromolyn.

Song-Yang Wu
Xi Jin
Yi-Zhou Jiang
Research25 Jun 2025
Nature Medicine

Volume: 31, P: 2405-2415
Collaborative optimization of layout and cutting scheduling for large-scale customized metal structural parts

Ronghua Meng
Jiayi Wang
Feng Guan
ResearchOpen Access21 Oct 2025
Scientific Reports

Volume: 15, P: 1-18
Hypertension in Chinese children: prevalence, phenotypes, stages, and associations with healthy lifestyles from a multi-visit study

Bing Zhu
Shuting Li
Peige Song
Research25 Nov 2025
Journal of Human Hypertension

P: 1-8
Universal temperature sensitivity of denitrification nitrogen losses in forest soils

Warming affects forest soil denitrification and nitrogen losses. The authors show that temperature enhances nitrous oxide and dinitrogen but varies by soil; temperature sensitivities are similar across soils but are higher for dinitrogen, suggesting complete denitrification in a warmer climate.

Haoming Yu
Yihang Duan
Yunting Fang
Research22 Jun 2023
Nature Climate Change

Volume: 13, P: 726-734
Influence of blade installation angle spanwise distribution on the energy characteristics of mining contra-rotating axial flow fan

Yongping Chen
Ronghua Liu
Xuan Zhou
ResearchOpen Access22 Feb 2025
Scientific Reports

Volume: 15, P: 1-22
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

John Luk and colleagues report the sequencing of 81 hepatitis B virus (HBV)-positive and 7 HBV-negative hepatocellular carcinomas and matched normal tissues. They confirm recurrent integration events of HBV at TERT and MLL4 and report recurrent events at the CCNE1 gene.

Wing-Kin Sung
Hancheng Zheng
John M Luk
Research27 May 2012
Nature Genetics

Volume: 44, P: 765-769
HMGB1 contributes to SASH1 methylation to attenuate astrocyte adhesion

Ronghua Wu
Yingying Yan
Liu Yang
ResearchOpen Access28 May 2019
Cell Death & Disease

Volume: 10, P: 1-12
Poly(I:C) preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway

Erya Chen
Chan Chen
Jin Liu
ResearchOpen Access06 Nov 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-15
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth

Fangda Fu
Ronghua Bao
Hongfeng Ruan
ResearchOpen Access12 Jan 2021
Scientific Reports

Volume: 11, P: 1-15
Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

Xin Wang
Jie Zhang
Jun Liu
ResearchOpen Access12 Jun 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
Water-use efficiency of an old-growth forest in lower subtropical China

Xiaodong Liu
Xiuzhi Chen
Jiyue Li
ResearchOpen Access21 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia

Ying Fu
Baichao Yu
Yiwei Chu
Research11 Dec 2023
Cellular & Molecular Immunology

Volume: 21, P: 19-32
Junctional and somatic hypermutation-induced CX₄C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody

Chunyan Yi
Jing Xia
Bing Sun
Research31 Mar 2020
Cellular & Molecular Immunology

Volume: 18, P: 675-685
Sex-differential association of suicide attempts with thyroid dysfunction in first-episode and drug-naïve young major depressive disorder patients with comorbid anxiety

Gang Ye
Ying Yuan
Xiangyang Zhang
ResearchOpen Access22 Aug 2023
Scientific Reports

Volume: 13, P: 1-9
Characteristics of serum metabolites in sporadic amyotrophic lateral sclerosis patients based on gas chromatography-mass spectrometry

Rui Jia
Qiaoyi Chen
Jingxia Dang
ResearchOpen Access21 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Rongjia Zhu
Tingdong Yan
Robert Chunhua Zhao
ResearchOpen Access26 Oct 2021
Cell Research

Volume: 31, P: 1244-1262
Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis

Jun Wu
Dingyun Song
Jie Hao
ResearchOpen Access16 Jun 2020
Cell Research

Volume: 30, P: 794-809
Fluorescence- and magnetic-activated cell sorting strategies to separate spermatozoa involving plural contributors from biological mixtures for human identification

Yan Xu
Jianhui Xie
Rui Li
ResearchOpen Access18 Nov 2016
Scientific Reports

Volume: 6, P: 1-12

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