Semi-synthesis of artemisinin has been achieved by autooxidation of dihydroartemisinic acid (DHAA), but DHAA supply relies on chemical synthesis from artemisinic acid. Here, authors report the identification of dihydroartemisinic acid dehydrogenase from Artemisia annua and its engineering for DHAA bioproduction in yeast.
- Zizheng Guo
- Ying Zhou
- Jianhua Zhu