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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer

The spatial architecture of the lung cancer microenvironment could influence the survival outlook and therapeutic options of patients. Here the authors find distinct patterns and composition of immune cells when comparing lung adenocarcinomas and lung squamous cell carcinomas, paving way for precision immune therapy according to histological subtype.

Lysanne Desharnais
Mark Sorin
Logan A. Walsh
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-12
Neutrophil extracellular traps in cancer

Neutrophil extracellular traps (NETs) influence cancer initiation, progression and metastasis through immunosuppressive mechanisms within the tumour microenvironment. In this Review, Shahzad et al. highlight our recent understanding of NET biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies.

Muhammad H. Shahzad
Roni F. Rayes
Jonathan D. Spicer
Reviews12 Nov 2025
Nature Reviews Cancer

Volume: 26, P: 104-117
Single-cell spatial landscapes of the lung tumour immune microenvironment

Using imaging mass cytometry, the tumour and immunological spatial landscapes of 416 lung adenocarcinomas are characterized, which, when combined with deep learning, can predict clinical outcomes with high accuracy.

Mark Sorin
Morteza Rezanejad
Logan A. Walsh
ResearchOpen Access01 Feb 2023
Nature

Volume: 614, P: 548-554
Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

Radioresistance remains a challenge in the treatment of bladder cancer. In this study, the authors show in mice that radiation increases deposits of neutrophil extracellular traps (NETs) via a TLR4-dependent mechanism and that NETs-targeting strategies can improve the response to radiotherapy.

Surashri Shinde-Jadhav
Jose Joao Mansure
Wassim Kassouf
ResearchOpen Access13 May 2021
Nature Communications

Volume: 12, P: 1-14
Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration

Quail and colleagues demonstrate that neutrophil-derived ROS and extracellular traps (NETs) mediate breast cancer metastasis to the lungs by altering endothelial junctional adhesions, thus favoring vascular permeability and transendothelial migration of cancer cells.

Sheri A. C. McDowell
Robin B. E. Luo
Daniela F. Quail
Research03 May 2021
Nature Cancer

Volume: 2, P: 545-562
Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis

George Vaniotis
Roni F. Rayes
Pnina Brodt
Research13 Apr 2018
Oncogene

Volume: 37, P: 3790-3805
C3a elicits unique migratory responses in immature low-density neutrophils

Brian E. Hsu
Joannie Roy
Peter M. Siegel
Research04 Feb 2020
Oncogene

Volume: 39, P: 2612-2623
International consensus guidelines for scoring the histopathological growth patterns of liver metastasis

Pieter-Jan van Dam
Eric P van der Stok
Peter B Vermeulen
ReviewsOpen Access05 Oct 2017
British Journal of Cancer

Volume: 117, P: 1427-1441

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