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Showing 1–6 of 6 results
Advanced filters: Author: Roni Weiss Clear advanced filters

  • Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity and identified potential therapeutic targets.

    • Brian M. Andersen
    • Camilo Faust Akl
    • Francisco J. Quintana
    Research
    Nature
    Volume: 644, P: 1097-1106

  • RNA sequencing, ribosome profiling and metabolic labelling of newly synthesized RNA reveal the strategy used by SARS-CoV-2 to shut off cellular protein synthesis in the host and allow the translation of viral transcripts.

    • Yaara Finkel
    • Avi Gluck
    • Noam Stern-Ginossar
    Research
    Nature
    Volume: 594, P: 240-245

  • APOBEC3G is a cytidine deaminase that can be incorporated into HIV-1 virions and process the viral genome upon cell infection, leading to viral hypermutation and inactivation. APOBEC3G's activities are counteracted by viral protein Vif. Using a sensitive enzymatic assay, low levels of APOBEC3G can be detected associated to Vif(+) virions. Furthermore, the authors show that APOBEC3G functions in a distributive manner and causes dispersed hypermutation via intersegmental transfer.

    • Roni Nowarski
    • Elena Britan-Rosich
    • Moshe Kotler
    Research
    Nature Structural & Molecular Biology
    Volume: 15, P: 1059-1066