Nature Search

Diversification of molecular pattern recognition in bacterial NLR-like proteins

Avs proteins are bacterial anti-phage pattern recognition receptors evolutionarily related to eukaryotic NLRs. Here, Béchon et al show that a single bacterial Avs can recognize different phage proteins as a signature for infection, explaining the broad defensive range of Avs proteins.

Nathalie Béchon
Nitzan Tal
Rotem Sorek
ResearchOpen Access14 Nov 2024
Nature Communications

Volume: 15, P: 1-15
Phage therapy with nebulized cocktail BX004-A for chronic Pseudomonas aeruginosa infections in cystic fibrosis: a randomized first-in-human trial

In a randomized, placebo-controlled trial, an inhaled phage cocktail was well tolerated in adults with cystic fibrosis and chronic Pseudomonas aeruginosa infection, with evidence of lung delivery and signs of bacterial reduction.

Iddo Weiner
Maya Kahan-Hanum
Merav Bassan
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Transcatheter edge-to-edge mitral valve repair in patients with severe left ventricular dilatation

Roy Raphael
Rotem Tal-Ben Ishay
Paul Fefer
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Bacteria deplete deoxynucleotides to defend against bacteriophage infection

Depletion of the deoxynucleotide pool by a family of dCTP deaminases, and a family of dGTPases, defends bacteria against phage infection.

Nitzan Tal
Adi Millman
Rotem Sorek
Research11 Jul 2022
Nature Microbiology

Volume: 7, P: 1200-1209
Antiviral activity of bacterial TIR domains via immune signalling molecules

The mechanism of Thoeris—a bacterial anti-phage defence system—is described in detail, revealing that bacterial TIR-domain proteins recognize infection and produce signalling molecules to execute cell death, akin to the roles of these proteins in plants.

Gal Ofir
Ehud Herbst
Rotem Sorek
Research01 Dec 2021
Nature

Volume: 600, P: 116-120
Prokaryotic viperins produce diverse antiviral molecules

Eukaryotic viperins originated from a clade of bacterial and archaeal proteins that catalyse the production of antiviral molecules.

Aude Bernheim
Adi Millman
Rotem Sorek
Research16 Sept 2020
Nature

Volume: 589, P: 120-124
Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

A study identifies 41 consensus gene expression meta-programs that are coordinately upregulated in subpopulations of malignant cells across tumour types, providing a comprehensive picture of hallmarks of intratumour heterogeneity.

Avishai Gavish
Michael Tyler
Itay Tirosh
Research31 May 2023
Nature

Volume: 618, P: 598-606
De-novo protein function prediction using DNA binding and RNA binding proteins as a test case

Identification of the function of proteins is difficult when there are no structurally or biochemically characterized homologs. Here, the authors present an approach that allows the prediction of nucleic-acid binding proteins based on sequence alone, and they are able to experimentally validate their method.

Sapir Peled
Olga Leiderman
Yanay Ofran
ResearchOpen Access21 Nov 2016
Nature Communications

Volume: 7, P: 1-9
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

Single-cell RNA-seq of a collection of 200 cancer cell lines finds common, recurrent heterogeneous expression programs, which also are found in patient samples and are linked to cell state and drug sensitivity.

Gabriela S. Kinker
Alissa C. Greenwald
Itay Tirosh
Research30 Oct 2020
Nature Genetics

Volume: 52, P: 1208-1218
ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models

Nimrod Rotem
Iddo Magen
Eran Perlson
ResearchOpen Access16 Mar 2017
Scientific Reports

Volume: 7, P: 1-17
Children’s perception of interpersonal coordination during joint painting

Rotem Abraham
Noemí Grinspun
Tal-Chen Rabinowitch
ResearchOpen Access07 Nov 2022
Scientific Reports

Volume: 12, P: 1-12
The pan-immune system of bacteria: antiviral defence as a community resource

In this Perspective article, Bernheim and Sorek present the ‘pan-immune system’ model in which bacteria employ horizontal gene transfer to access immune defence mechanisms encoded by closely related strains, and conclude by discussing the implications on the evolution of anti-defence strategies in phages.

Aude Bernheim
Rotem Sorek
Reviews06 Nov 2019
Nature Reviews Microbiology

Volume: 18, P: 113-119
Housing RCS rats under specific pathogen-free conditions mildly ameliorates retinal degeneration and alters intestine microbiota

Hadas Ketter-Katz
Rawan Saeed
Ygal Rotenstreich
ResearchOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-14
Characterization of alternative mRNA splicing in cultured cell populations representing progressive stages of human fetal kidney development

Yishay Wineberg
Itamar Kanter
Tomer Kalisky
ResearchOpen Access15 Nov 2022
Scientific Reports

Volume: 12, P: 1-13
CRISPR-Cas9 editing of TLR4 to improve the outcome of cardiac cell therapy

Yeshai Schary
Itai Rotem
Jonathan Leor
ResearchOpen Access18 Mar 2023
Scientific Reports

Volume: 13, P: 1-16

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Diversification of molecular pattern recognition in bacterial NLR-like proteins

Phage therapy with nebulized cocktail BX004-A for chronic Pseudomonas aeruginosa infections in cystic fibrosis: a randomized first-in-human trial

Transcatheter edge-to-edge mitral valve repair in patients with severe left ventricular dilatation

Bacteria deplete deoxynucleotides to defend against bacteriophage infection

Antiviral activity of bacterial TIR domains via immune signalling molecules

Prokaryotic viperins produce diverse antiviral molecules

Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

De-novo protein function prediction using DNA binding and RNA binding proteins as a test case

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models

Children’s perception of interpersonal coordination during joint painting

The pan-immune system of bacteria: antiviral defence as a community resource

Housing RCS rats under specific pathogen-free conditions mildly ameliorates retinal degeneration and alters intestine microbiota

Characterization of alternative mRNA splicing in cultured cell populations representing progressive stages of human fetal kidney development

CRISPR-Cas9 editing of TLR4 to improve the outcome of cardiac cell therapy

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