Triple artemisinin-based combination therapies, including mefloquine–piperaquine (MQ–PPQ), may delay emergence of multidrug-resistant strains. Here the authors show that resistance to mefloquine alone reduces the efficacy of the MQ-PPQ combination therapy, and that the interaction between the two drugs further inhibits piperaquine’s activity.
- Camille Roesch
- Anna Cosson
- Benoit Witkowski
