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Showing 1–15 of 15 results
Advanced filters: Author: Roy van der Meel Clear advanced filters

  • Efficient and targeted delivery of nucleic acids is critical for realizing the full therapeutic potential of gene editing, vaccines and RNA-based drugs, and emerging delivery platforms offer innovative solutions through their diverse architectures, tunable properties and distinct biological interactions. In this Viewpoint, researchers working across different delivery platforms — including lipid nanoparticles, synthetic polymers, peptide amphiphiles, coacervate microdroplets, DNA nanostructures and extracellular vesicles — discuss the most promising directions and the main challenges in shaping the future of nucleic acid delivery.

    • Roy van der Meel
    • Paul A. Wender
    • Paola Luciani
    Reviews
    Nature Reviews Materials
    Volume: 10, P: 490-499

  • Delivering immunomodulatory compounds to myeloid cells can activate innate immunity for cancer immunotherapy. Here the authors design a polymersome-based nanocarrier for delivering β-glucan to red pulp myeloid cells in the spleen and show that their strategy achieves tumour growth reduction in a melanoma model.

    • Annelies C. Wauters
    • Jari F. Scheerstra
    • Jan C. M. van Hest
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 19, P: 1735-1744

  • Combining machine learning with high-throughput synthesis expedites ionizable cationic lipid development for nanoparticle-based messenger RNA delivery.

    • Roy van der Meel
    • Francesca Grisoni
    • Willem J. M. Mulder
    News & Views
    Nature Materials
    Volume: 23, P: 880-881

  • PEGylated liposomal accumulation in inflamed regions has mainly been attributed to the enhanced permeation and retention effect. An arthritis model that chemotactically attracted myeloid cells shows that monocytes and neutrophils play an essential role in liposome delivery towards inflamed joints.

    • Joke Deprez
    • Rein Verbeke
    • Ine Lentacker
    Research
    Nature Nanotechnology
    Volume: 18, P: 1341-1350

  • Lipid nanoparticles containing genetic drugs can be bioengineered to tune their biodistribution and induce organ-specific gene regulation.

    • Roy van der Meel
    News & Views
    Nature Nanotechnology
    Volume: 15, P: 253-255

  • Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells, by potentiating its anti-oedema activity and by exploiting its anti-fibrotic effects.

    • Twan Lammers
    • Alexandros Marios Sofias
    • Josbert M. Metselaar
    Comments & Opinion
    Nature Nanotechnology
    Volume: 15, P: 622-624

  • The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves the way for clinical development of many nucleic acid-based therapies enabled by nanoparticle delivery.

    • Akin Akinc
    • Martin A. Maier
    • Pieter R. Cullis
    Comments & Opinion
    Nature Nanotechnology
    Volume: 14, P: 1084-1087

  • The use of nanomedicine in cancer requires the adoption of specific strategies to optimize its potential. This perspective proposes four strategies including the identification of patients for clinical trials, investments in modular nanocarrier design, the integration in multimodal combination therapy regimes and the inclusion in immunotherapy studies

    • Roy van der Meel
    • Einar Sulheim
    • Twan Lammers
    Reviews
    Nature Nanotechnology
    Volume: 14, P: 1007-1017

  • This Review provides an overview of four platform technologies that are currently used in the clinic for delivery of nucleic acid therapeutics, describing their properties, discussing technical advancements that led to clinical approval, and highlighting examples of approved genetic drugs that make use of these technologies.

    • Jayesh A. Kulkarni
    • Dominik Witzigmann
    • Roy van der Meel
    Reviews
    Nature Nanotechnology
    Volume: 16, P: 630-643

  • Cytokines are key regulators of the immune system and can be recombinantly designed as therapeutics for immune-related disorders. However, the severe toxicity of recombinant cytokines limits their clinical translation. In this Review, the authors highlight bioengineering approaches for the design of clinically applicable and safe cytokine-based therapeutics.

    • Jeroen Deckers
    • Tom Anbergen
    • Willem J. M. Mulder
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 286-303