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An enhanced superconducting pairing temperature (T_g) has only been observed in single-layer FeSe interfaced with TiO_x system. Here, the authors construct a new interface composed of single-layer FeSe interfaced with LaFeO₃ showing a highest T_g of 80 K among all-known interfacial superconductors.

Using a multi-layer metasurface array in which each meta-atom of the metasurface acts as an active artificial neuron, a programmable diffractive deep neural network can be created that directly processes electromagnetic waves in free space for wave sensing and wireless communications.

Tumor-associated macrophages support an immunosuppressive tumor microenvironment. Di Conza et al. uncover how IRE1–XBP1 and IRE1−STAT3 endoplasmic reticulum stress responses pathways are engaged by tumor-derived lipids to orchestrate pro-tumorigenic features and survival in tumor-associated macrophages.

Laser-printed gold metasurface supporting symmetry-protected plasmonic quasi-bound states in the continuum (qBIC) was fabricated, comprehensively characterized and applied to demonstrate the first qBIC-empowered field-effect transistor device with HgTe quantum dot active medium.

This work reports a dual transposase–peroxidase fusion to survey the accessible chromatin regions and the proximal proteome in one assay, providing a tool to capture both the genomic and proteomic contents of open chromatin.

Yamanaka factors can reprogram somatic and cancer cells into induced pluripotent stem cells. Here, the authors show that the induction of these factors in acute myeloid leukemia leads to apoptosis of leukemia cells in vivo, and this is through modulation of chromatin accessibility to apoptotic genes and accompanied by H3K9me3 dysregulation.

Despite the rich coordination chemistry, hydroxylamines are rarely used as ligands for transition metal coordination compounds. Here the authors designed macrocyclic poly-N-hydroxylamines that form complexes containing a d-metal ion and coordinate by up to six hydroxylamine fragments.

Carbon atoms of various species typically function as acceptors of noncovalent interactions when they are part of a π-system. Here, the authors report their discovery of a noncovalent halogen bond involving the isocyano carbon lone pair, which results in adducts with strongly reduced isocyanide odor.

Mechanisms regulating the formation of pre-metastatic niches remain poorly understood. Here, the authors show that ITGBL1-containing extracellular vesicles derived from primary colorectal cancer cells activate the production of inflammatory cytokines by resident fibroblasts in distant organs, promoting metastatic cancer growth.

cGAS is an important mediator of antiviral immune responses, but the regulation of its activity is unknown. Here, the authors identify a zinc finger protein, ZCCHC3, that enhances the binding of cGAS to dsDNA and is important for its activation following viral infection.

Intelligent sensing technologies gain interest for the internet of things and applications that require collection and analysis of big data. Here the authors report a flexible and durable wood-based triboelectric nanogenerator for self-powered sensing in athletic big data analytics.

EY6A, a neutralizing antibody isolated from a patient convalescing from COVID-19, binds the receptor binding domain of the SARS-CoV-2 spike glycoprotein with high affinity, at a location away from the binding site for the ACE2 receptor, similar to the one recognized by CR3022.

Low-dose IL-2 treatment alters the abundance of regulatory T cells, IL-17-producing T cells and follicular helper T cells, but not of T helper type 1 and 2 cells, in patients with SLE.

A combination of norbornene and pyridine-type ligand enables commonly used ortho-directing groups to direct meta-C–H activation with palladium catalysts.

Intraventricular hemorrhage is one of the most fatal forms of brain injury. It is a common complication in premature infants and has limited treatment options. Here, the authors show that transcranial photostimulation can ameliorate lymphatic removal of blood from the brain of adult and newborn rodents after intraventricular hemorrhage, providing fast recovery and improvement of behavioral outcomes.

Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures, which give insights into the mechanism and reveal a second small molecule binding site, which is of interest for drug design.

Josephson vortices (JVs) play an important role in superconducting quantum devices, but they remain difficult to be observed and manipulated. Here, Dremov et al. report magnetic fingerprint of JVs in magnetic force microscopy experiments, which paves a way to generate and control JVs.

Manipulating magnetic orders by electric fields promises energy efficient spintronic applications. Here the authors demonstrate electrical control of s-p exchange interaction in a ferromagnet-semiconductor quantum well structure due to the phononic ac Stark effect.

Owing to long spin lifetime and diffusion length, graphene holds promise for spintronics, yet it does not possess intrinsic magnetic properties. Here, the authors observe experimentally a large, positive magnetoresistance at graphene nanodomain boundaries.

Integration of ferromagnetic and semiconducting elements is important for future devices capable of both processing and storing information. Korenevet al. describe a novel spin-separation effect in a ferromagnet/semiconductor quantum well hybrid and show the optical readout of hysteresis loops.

A small molecule that disrupts interaction between Nur77 and LKB1 leads to LKB1 exit from the nucleus to activate cytoplasmic AMPK and, ultimately, reduces blood glucose and insulin in diabetic mice.

Smad3, a transcription factor activated by TGF-β, has been implicated in tumorigenesis. Here the authors show that Smad3 inhibits NK cell differentiation and effector function by repressing NFIL3, and that genetic or pharmacological blockade of Smad3 expands tumour-suppressive NK cells and restricts tumour growth in mice.

Inherited congenital heart defects are prevalent in the human population, but the molecular mechanisms are poorly understood. In this article, deficiency in the chromatin remodelling factor, Brg1, is shown to alter cardiac development in both mouse and zebrafish laboratory models.

The authors identify programmed cell death ligand-1 (PD-L1), an immunity suppressor produced by cancer cells, as a new pain inhibitor and a neuromodulator. They report that PD-L1 is produced by melanoma and normal neural tissues and that it inhibits acute and chronic pain. Via activation of PD-1, its receptor, PD-L1 decreases the excitability of nociceptive neurons in mouse and human dorsal root ganglia.

Exchange interactions are typically short-ranged as they depend on wavefunction overlap, but a long-ranged exchange is now seen in a hybrid ferromagnet–semiconductor system, which may be mediated by elliptically polarized phonons.

By examining three model pyroelectric materials with different bonding characters along the out-of-plane direction, it is shown that their pyroelectric coefficients increase rapidly when the thickness of free-standing sheets becomes small.