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Showing 1–6 of 6 results
Advanced filters: Author: Ru-Juan Liu Clear advanced filters

  • The NSUN family, comprising seven members, is the primary RNA m5C methyltransferase in higher eukaryotes. Here, the authors demonstrate that NSUN7 is a catalytically inactive RNA m5C protein due to sequence variations in its motif IV. Instead, the authors reveal a noncatalytic, regulatory role of NSUN7 in sperm flagellum assembly.

    • Jing Li
    • Wen-Yu Zhu
    • Ru-Juan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • mRNA modifications like m5C are typically introduced by tRNA-modifying enzymes, while the catalytic mechanism and function remain debated. Here, the authors show that NSUN6 catalyzes tRNA and mRNA substrates in different ways, and that NSUN6 promotes breast cancer cell migration through mRNA m5C modification.

    • Yuan-Yuan Zhang
    • Cai-Tao Li
    • Ru-Juan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Naive T cells are quiescent but undergo dynamic changes upon antigenic activation. Li and colleagues show that upregulation of tRNA methyltransferase complex TRMT61A–TRMT6 and N1-methyladenosine modification of tRNAs contribute to accelerated mRNA translation efficiency, in particular that of MYC protein, and are required for rapid T cell proliferation.

    • Yongbo Liu
    • Jing Zhou
    • Hua-Bing Li
    Research
    Nature Immunology
    Volume: 23, P: 1433-1444

  • Zhang et al. identify ALKBH7 as the demethylase of mitochondrial pre-tRNAs that regulates nascent mitochondrial RNA processing and translation. ALKBH7 loss impairs mitochondrial functions including fatty acid oxidation, leading to obesity.

    • Li-Sheng Zhang
    • Qing-Ping Xiong
    • Chuan He
    Research
    Nature Cell Biology
    Volume: 23, P: 684-691

  • tRNA-derived small RNAs (tdRs) have long been considered mere intermediates of tRNA degradation. This Review discusses the biogenesis and regulation of tdRs and focuses on their emerging gene regulation roles in cell metabolism, immune responses, development and cancer.

    • Sowndarya Muthukumar
    • Cai-Tao Li
    • Cristian Bellodi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 359-378