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Showing 1–8 of 8 results
Advanced filters: Author: Rudi Fasan Clear advanced filters

  • Despite advances in enzyme design and engineering, the development of biocatalysts featuring a combination of tailored stereoselectivity with broad substrate scope has been very difficult. Focusing on a new-to-nature reaction, the authors report a mechanism-based, multi-state computational design workflow for the generation of ‘generalist’ cyclopropanases capable of transforming a broad range of substrates with tailored and divergent stereoselectivity.

    • Zhuofan Shen
    • Mary G. Siriboe
    • Rudi Fasan
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • The 2025 RepArtZymes conference featured the latest developments in the design and development of artificial and repurposed enzymes for synthetic and biotechnological applications. These contributions illustrate the impact of this rapidly expanding research area towards addressing key challenges in organic synthesis, medicinal chemistry, polymer chemistry, energy conversion, and environmental remediation.

    • Rudi Fasan
    News & Views
    Nature Catalysis
    Volume: 8, P: 867-869

  • The use of biocatalysis to support early-stage drug discovery campaigns remains largely untapped. Here, engineered biocatalysts enable the synthesis of sp3-rich polycyclic compounds through an intramolecular cyclopropanation of benzothiophenes, affording a class of complex scaffolds potentially useful for fragment-based drug discovery campaigns.

    • David A. Vargas
    • Xinkun Ren
    • Rudi Fasan
    Research
    Nature Chemistry
    Volume: 16, P: 817-826

  • Hemoproteins have recently emerged as promising biocatalysts for carbene transfer reactions but mechanistic understanding of the interplay between productive and unproductive pathways in these processes is limited. Here, the authors use a combination of spectroscopic, crystallographic, and computational tools to elucidate the mechanism of a recently reported myoglobin-catalyzed cyclopropanation reaction with diazoketones.

    • Donggeon Nam
    • John-Paul Bacik
    • Rudi Fasan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Chiral lactams are important pharmacophores and strategies for their synthesis through direct C–H functionalization are highly sought after. Now, intramolecular C–H amidation of dioxazolones via biocatalytic nitrene transfer enables the synthesis of enantioenriched lactams with various ring sizes.

    • Satyajit Roy
    • David A. Vargas
    • Rudi Fasan
    Research
    Nature Catalysis
    Volume: 7, P: 65-76

  • Two papers provide insight into the reactivity of cytochrome P450s. A direct link between electron donation and reactivity has been shown with a selenocysteine-ligated P450 compound I, whereas a serine-ligated P450 (P411) has been engineered to catalyse an intermolecular C–H amination via nitrene transfer.

    • Rudi Fasan
    News & Views
    Nature Chemistry
    Volume: 9, P: 609-611

  • The introduction of single abiological catalytic groups enables enzymes to catalyse new-to-nature chemical transformations. Now, this concept is extended to two abiological groups in a single protein scaffold to allow synergistic catalysis in a stereoselective Michael addition reaction.

    • Xinkun Ren
    • Rudi Fasan
    News & Views
    Nature Catalysis
    Volume: 3, P: 184-185