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Showing 1–11 of 11 results
Advanced filters: Author: Ruiz De Los Mozos Igor Clear advanced filters

  • Cells rely on tightly controlled RNA splicing to ensure proper gene expression. Here, the authors show that CDK11-driven phosphorylation of SF3B1 recruits SNIP1 and the RES complex to activate the spliceosome, uncovering a signaling pathway essential for accurate splicing, cell survival, and disease prevention.

    • Pavla Gajdušková
    • Igor Ruiz de Los Mozos
    • Dalibor Blazek
    ResearchOpen Access
    Nature Communications
    P: 1-21

  • Rapid immune activation requires tight control of mRNA stability in CD8⁺ T cells. Here, the authors show that a compositive RNA motif – m⁶A sites positioned next to AU-rich elements - marks mRNAs for rapid decay during activation, revealing a coordinated mechanism that shapes T-cell immunity.

    • Paulo A. Gameiro
    • Iosifina P. Foskolou
    • Jernej Ule
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • CDK11 functions with histone pre-mRNA-processing factor FLASH to upregulate expression of replication-dependent histone genes in S phase and to couple transcription and processing of nascent histone transcripts in mammalian cells.

    • Pavla Gajdušková
    • Igor Ruiz de los Mozos
    • Dalibor Blazek
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 500-510

  • The microbiota of the intestinal tract is considered a large biofilm formed by myriads bacteria that have a considerable impact in health and disease. Here, the authors show that biofilm-associated proteins from intestinal microbiota form amyloid-like structures that exacerbate alpha-synuclein pathologies.

    • Ariadna Fernández-Calvet
    • Leticia Matilla-Cuenca
    • Jaione Valle
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Here the authors show that, upon embryo implantation, signaling triggers a large-scale rearrangement of protein–RNA interactions. Phosphorylated LIN28A reassembles onto the 3′ untranslated region termini of pluripotency-associated mRNAs, where it converges with the binding of poly(A)-binding protein and drives selective mRNA decay.

    • Miha Modic
    • Klara Kuret
    • Jernej Ule
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1439-1447

  • CDK11 associates with SF3B1 and phosphorylates threonine residues at the N terminus of SF3B1 during spliceosome activation, and the inhibition of CDK11 blocks the activation and leads to widespread intron retention and the accumulation of non-functional spliceosomes on pre-mRNAs and chromatin.

    • Milan Hluchý
    • Pavla Gajdušková
    • Dalibor Blazek
    Research
    Nature
    Volume: 609, P: 829-834

  • Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. Here, the authors show that Staphylococcus aureus can survive in the absence of all its 16 TCSs under growth arrest conditions, and each TCS seems to be sufficient to sense and respond to specific environmental clues.

    • Maite Villanueva
    • Begoña García
    • Iñigo Lasa
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The RNA-binding protein SRSF7 autoregulates its protein levels through an intricate negative feedback mechanism that involves translation of two distinct protein halves, termed Split-ORFs; the potential to encode Split-ORFs is also seen in other targets of nonsense-mediated decay.

    • Vanessa Königs
    • Camila de Oliveira Freitas Machado
    • Michaela Müller-McNicoll
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 260-273