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Advanced filters: Author: Ruo-Fei Tian Clear advanced filters

Lactate mitochondrial oxidation drives stemness potential in metastatic breast cancer

Metastatic cancer cells rely on metabolic flexibility to survive. Here, the authors show that metastatic breast cancer cells use lactate for mitochondrial oxidation via the CD147/MCT1/LDHB complex to sustain stemness and promote metastasis.

Jia-Jia Zhang
Ruo-Fei Tian
Ling Li
ResearchOpen Access18 Dec 2025
Nature Communications

Volume: 17, P: 1-24
CD147 supports paclitaxel resistance via interacting with RanBP1

Gang Nan
Shu-Hua Zhao
Hong-Yong Cui
ResearchOpen Access01 Jan 2022
Oncogene

Volume: 41, P: 983-996
CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression

Hong-Yong Cui
Shi-Jie Wang
Zhi-Nan Chen
ResearchOpen Access14 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-15