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Showing 1–3 of 3 results
Advanced filters: Author: Ruochong Li Clear advanced filters

  • Piezo1, a mechanosensitive cation channel, senses shear stress of blood flow for proper blood vessel development, regulates red blood cell function and controls cell migration and differentiation; here a trimeric architecture of this novel class of ion channel is reported, suggesting that Piezo1 may use its peripheral propeller-like ‘blades’ as force sensors to gate the central ion-conducting pore.

    • Jingpeng Ge
    • Wanqiu Li
    • Maojun Yang
    Research
    Nature
    Volume: 527, P: 64-69

  • Neutral sphingomyelinases play pivotal roles in ceramide-related signaling transduction. Here, the authors solve the structure of human neutral sphingomyelinase SMPD2 and propose a catalytic mechanism, potentially enhancing understanding of ceramide in disease and cancer treatment.

    • Jingbo Yi
    • Boya Qi
    • Maojun Yang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13