Nature Search

Challenges and opportunities in 2021

Twelve early-career investigators share their thoughts on the challenges faced by their teams and communities during the past year, and look ahead to new opportunities for 2022.

Leila Akkari
Stacey D. Finley
Meng Michelle Xu
Reviews21 Dec 2021
Nature Cancer

Volume: 2, P: 1278-1283
Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

The MiT/TFE family of transcription factors is found to coordinate constitutive activation of autophagy and lysosome biogenesis to drive the metabolic programming and malignant growth of pancreatic cancer.

Rushika M. Perera
Svetlana Stoykova
Nabeel Bardeesy
Research13 Jul 2015
Nature

Volume: 524, P: 361-365
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer

PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-high cells preferring the lung.

Gilles Rademaker
Grace A. Hernandez
Rushika M. Perera
Research21 May 2025
Nature

Volume: 643, P: 1381-1390
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity

Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC mRNA translation regulators and identify RBM42 as a ribosome-associated protein that modulates translation of MYC and an oncogenic mRNA programme required for pancreatic cancer growth.

Joanna R. Kovalski
Goksu Sarioglu
Davide Ruggero
Research04 Feb 2025
Nature Cell Biology

Volume: 27, P: 518-529
Correction: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son
Costas A. Lyssiotis
Alec C. Kimmelman
Amendments and Corrections12 Jun 2013
Nature

Volume: 499, P: 504
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

Gupta et al. show that the membrane repair factor Myoferlin protects against membrane damage of pancreatic cancer lysosomes to sustain enhanced lysosomal function and promote tumour growth.

Suprit Gupta
Julian Yano
Rushika M. Perera
Research08 Mar 2021
Nature Cell Biology

Volume: 23, P: 232-242
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Inhibition of the autophagy–lysosome system upregulates surface expression of MHC class I proteins and enhances antigen presentation, and evokes a potent anti-tumour immune response that is mediated by CD8⁺ T cells.

Keisuke Yamamoto
Anthony Venida
Alec C. Kimmelman
Research22 Apr 2020
Nature

Volume: 581, P: 100-105
When antioxidants are bad

Reactive oxygen species (ROS) get a bad press, as evidenced by the notable trend in the use of dietary and cosmetic antioxidants. New work suggests, however, that ROS might have a role in mitigating certain cancers. See Letter p.106

Rushika M. Perera
Nabeel Bardeesy
News & Views06 Jul 2011
Nature

Volume: 475, P: 43-44
Dengue virus dominates lipid metabolism modulations in Wolbachia-coinfected Aedes aegypti

Koh, Islam, Ye et al. describe lipid profiles of Aedes aegypti mosquitoes bearing mono- or dual-infections of Wolbachia (wMel) and dengue virus serotype 3 (DENV3), finding that virus modulation dominates the dual-infection lipid profile and that cardiolipins support DENV3 and Wolbachia replication. This study suggests that direct competition for lipids do not underlie Wolbachia-mediated virus blocking.

Cassandra Koh
M. Nurul Islam
Elizabeth A. McGraw
ResearchOpen Access18 Sept 2020
Communications Biology

Volume: 3, P: 1-14
Functional characterization of Alzheimer’s disease genetic variants in microglia

Genetic fine-mapping and CRISPRi screens identify functional variants and their target genes associated with Alzheimer’s disease in microglia. The variant rs7922621 modulates AD risk through control of TSPAN14 expression in this cell type.

Xiaoyu Yang
Jia Wen
Yin Shen
Research21 Sept 2023
Nature Genetics

Volume: 55, P: 1735-1744
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology

Lysosomes orchestrate key cellular functions such as nutrient sensing, degradation of macromolecules and stress adaptation. This Review discusses the integration of signalling pathways at the lysosome and highlights the interaction of lysosomes with other organelles and mechanisms that ensure lysosome homeostasis.

Carmine Settembre
Rushika M. Perera
Reviews24 Nov 2023
Nature Reviews Molecular Cell Biology

Volume: 25, P: 223-245
Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularisand uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.

Monika Gulia-Nuss
Andrew B. Nuss
Catherine A. Hill
ResearchOpen Access09 Feb 2016
Nature Communications

Volume: 7, P: 1-13
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Pancreatic cancers use a novel glutamine metabolism pathway, regulated by oncogenic KRAS, to maintain redox balance; these findings add to the understanding of the mechanisms by which oncogenic alterations reprogram cellular metabolism to promote tumour growth.

Jaekyoung Son
Costas A. Lyssiotis
Alec C. Kimmelman
Research27 Mar 2013
Nature

Volume: 496, P: 101-105
The tumor-specific de2–7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR

Rodney B Luwor
Hong-Jian Zhu
Terrance G Johns
Research28 Jun 2004
Oncogene

Volume: 23, P: 6095-6104

Search

Challenges and opportunities in 2021

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer

Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity

Correction: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

When antioxidants are bad

Dengue virus dominates lipid metabolism modulations in Wolbachia-coinfected Aedes aegypti

Functional characterization of Alzheimer’s disease genetic variants in microglia

Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

The tumor-specific de2–7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR

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