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Cardiometabolic and molecular adaptations to 6-month intermittent fasting in middle-aged men and women with overweight: secondary outcomes of a randomized controlled trial

Intermittent fasting is investigated as an alternative to caloric restriction as a treatment modality for weight loss and improvement of cardiometabolic risk factors. Here the authors report the secondary and exploratory outcomes of a randomized controlled cross-over trial showing that six months of intermittent fasting reduced body weight and improved lipid profiles, which associated with altered GLP−1–related enteroendocrine signaling and B-cell pathways based on colon transcriptomics and plasma metabolimics.

Ruteja A. Barve
Nicola Veronese
Luigi Fontana
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 16, P: 1-14
The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice

The authors studied mice with targeted deletion of OPA1, a mitochondrial fusion protein, in intervertebral disc and knee articular cartilage, and showed that maintenance of mitochondrial dynamics is critical for the health of these hypoxic tissues

Vedavathi Madhu
Miriam Hernandaz-Meadows
Makarand V. Risbud
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-21
Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

Fibre snacks that target distinct features of the microbiomes of donors with obesity transplanted into gnotobiotic mice also lead to fibre-specific changes in the microbiome and physiology when used in controlled-diet human studies.

Omar Delannoy-Bruno
Chandani Desai
Jeffrey I. Gordon
Research23 Jun 2021
Nature

Volume: 595, P: 91-95
Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes

Environmental conditions during pregnancy contribute to offspring metabolic disease. Here, the authors show that immune cells reprogrammed in utero by maternal vitamin D deficiency increase lifetime diabetes risk in the offspring and are sufficient to transplant diabetes.

Jisu Oh
Amy E. Riek
Carlos Bernal-Mizrachi
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-18
Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice

Pranay Ramteke
Bahiyah Watson
Makarand V. Risbud
ResearchOpen Access08 May 2025
Bone Research

Volume: 13, P: 1-14
Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc

Takashi Ohnishi
Victoria Tran
Makarand V. Risbud
ResearchOpen Access19 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-16

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Cardiometabolic and molecular adaptations to 6-month intermittent fasting in middle-aged men and women with overweight: secondary outcomes of a randomized controlled trial

The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes

Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice

Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc

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Cardiometabolic and molecular adaptations to 6-month intermittent fasting in middle-aged men and women with overweight: secondary outcomes of a randomized controlled trial

The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes

Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice

Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc

Search

Quick links