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NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms

In JAK2V617F mutant myeloproliferative neoplasms (MPN), inflammation impacts clinical outcomes. This study uncovers that the NLRP3 inflammasome drives thrombocytosis, granulocytosis, HSPC expansion, splenomegaly, and bone marrow fibrosis in MPN

Ruth-Miriam Koerber
Calvin Krollmann
Lino L. Teichmann
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-16

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NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms

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