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INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model

Glioblastoma (GBM) is characterized by a high degree of heterogeneity and plasticity due to interplay with neural developmental programs. Here, the authors develop a model of GBM by introducing sequential oncogenic mutations in human neural stem cells and using this, identify INSM1 as a driver of a neural progenitor gene network promoting tumorigenesis.

Patrick A. DeSouza
Matthew Ishahak
Albert H. Kim
ResearchOpen Access07 Dec 2025
Nature Communications

Volume: 17, P: 1-18
Four-component protein nanocages designed by programmed symmetry breaking

Using viral capsid architectures as template for design, higher triangulation number nanocages that require symmetry breaking offer potential advances in targeted delivery and antigen-displaying vaccines.

Sangmin Lee
Ryan D. Kibler
David Baker
ResearchOpen Access18 Dec 2024
Nature

Volume: 638, P: 546-552
Correction: Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Cas Simons
Lachlan D Rash
Ryan J Taft
Amendments and Corrections25 Feb 2015
Nature Genetics

Volume: 47, P: 304
Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Cas Simons, Ryan Taft and colleagues report the identification of KCNH1 mutations in six individuals with Temple-Baraitser syndrome (TBS). Electrophysiological measurements of cells expressing mutant KCNH1 channels show decreased activation thresholds and slower deactivation in comparison to wild-type channels, suggesting that these mutations lead to gain of function of KCNH1.

Cas Simons
Lachlan D Rash
Ryan J Taft
Research24 Nov 2014
Nature Genetics

Volume: 47, P: 73-77
Haplotyping germline and cancer genomes with high-throughput linked-read sequencing

A microfluidics approach that links short sequence reads enables haplotype construction and complex variation identification from tiny amounts of input DNA.

Grace X Y Zheng
Billy T Lau
Hanlee P Ji
Research01 Feb 2016
Nature Biotechnology

Volume: 34, P: 303-311
Design of pseudosymmetric protein hetero-oligomers

Hetero-oligomeric proteins offer many advantages for bioengineering efforts but are difficult to make from scratch. Here, authors present a simple method for creating pseudosymmetric hetero-oligomers from input symmetrical proteins.

Ryan D. Kibler
Sangmin Lee
David Baker
ResearchOpen Access18 Dec 2024
Nature Communications

Volume: 15, P: 1-12
Genome-wide enhancer maps link risk variants to disease genes

Mapping enhancer regulation across human cell types and tissues illuminates genome function and provides a resource to connect risk variants for common diseases to their molecular and cellular functions.

Joseph Nasser
Drew T. Bergman
Jesse M. Engreitz
Research07 Apr 2021
Nature

Volume: 593, P: 238-243
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.

Vasanthi S. Viswanathan
Matthew J. Ryan
Stuart L. Schreiber
Research05 Jul 2017
Nature

Volume: 547, P: 453-457
Serum urate and cardiovascular events in the DCCT/EDIC study

Alicia J. Jenkins
Barbara H. Braffett
T. Woodfill
ResearchOpen Access09 Jul 2021
Scientific Reports

Volume: 11, P: 1-11

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INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model

Four-component protein nanocages designed by programmed symmetry breaking

Correction: Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Haplotyping germline and cancer genomes with high-throughput linked-read sequencing

Design of pseudosymmetric protein hetero-oligomers

Genome-wide enhancer maps link risk variants to disease genes

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Serum urate and cardiovascular events in the DCCT/EDIC study

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