Nature Search

A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts

Takeshi Todo
Hiroshi Takemori
Taisei Nomura
Research28 Jan 1993
Nature

Volume: 361, P: 371-374
Direct imaging of atomistic grain boundary migration

The atomic process of grain boundary migration has been directly observed by scanning transmission electron microscopy, revealing transformations between different stable or metastable grain boundary structures.

Jiake Wei
Bin Feng
Yuichi Ikuhara
Research11 Jan 2021
Nature Materials

Volume: 20, P: 951-955
Direct observation of substitutional and interstitial dopant diffusion in oxide grain boundary

Using electron microscopy, the authors demonstrate direct tracking of Hf dopant diffusion along the α-Al2O3 Σ31 grain boundary. Theoretical calculation elucidates that interstitial diffusion can greatly enhance diffusivity through shuffle motion.

Toshihiro Futazuka
Ryo Ishikawa
Yuichi Ikuhara
ResearchOpen Access17 Oct 2025
Nature Communications

Volume: 16, P: 1-10
Hyperthin nanochains composed of self-polymerizing protein shackles

The sophisticated structure of protein fibrils suggests that they may be useful nanomaterials. Here the authors design a series of self-polymerizing protein monomers, the reactions of which are controlled by redox chemistry, and show that functional units may also be incorporated into the extended structures.

Ryo Matsunaga
Saeko Yanaka
Kouhei Tsumoto
Research25 Jul 2013
Nature Communications

Volume: 4, P: 1-10
ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

The human protein APOBEC3G (A3G) inhibits HIV-1 replication, but the viral protein Vif counteracts by inducing A3G degradation. Here Miyakawa et al. show that the antiretroviral drug AZT restores A3G function in vitroby stimulating expression of a host protein, ASK1, which interferes with the action of Vif.

Kei Miyakawa
Satoko Matsunaga
Akihide Ryo
ResearchOpen Access22 Apr 2015
Nature Communications

Volume: 6, P: 1-10
The 1-minute sit-to-stand test to detect desaturation during 6-minute walk test in interstitial lung disease

Keiji Oishi
Kazuto Matsunaga
Masafumi Yano
ResearchOpen Access27 Jan 2022
npj Primary Care Respiratory Medicine

Volume: 32, P: 1-6
Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

In human cells, invading pathogens trigger an innate immune response that helps prevent viral replication and spread. Here, the authors reveal a mechanism of innate immunity that selectively leads to the autophagic degradation of hepatitis B virus core protein.

Kei Miyakawa
Mayuko Nishi
Akihide Ryo
ResearchOpen Access27 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Factors contributing to discrepant estimated glomerular filtration values measured by creatinine and cystatin C in patients with rheumatoid arthritis

Akikatsu Nakashima
Shigeto Horita
Mitsuhiro Kawano
ResearchOpen Access10 May 2021
Scientific Reports

Volume: 11, P: 1-8
The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein

The tumour suppressor APC is a multifunctional protein implicated in intracellular localization of mRNAs and WNT signalling. Here, Miyakawaet al. show that, via interaction with the HIV Gag precursor protein, APC promotes membrane targeting of viral components and cell-to-cell spread of HIV.

Kei Miyakawa
Mayuko Nishi
Akihide Ryo
ResearchOpen Access30 Jan 2017
Nature Communications

Volume: 8, P: 1-13
Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction

Genome-wide analyses in BioBank Japan and populations of European ancestry identify new risk loci for atrial fibrillation. A polygenic risk score constructed from the cross-ancestry meta-analysis is associated with increased risk of long-term cardiovascular mortality.

Kazuo Miyazawa
Kaoru Ito
Issei Komuro
ResearchOpen Access19 Jan 2023
Nature Genetics

Volume: 55, P: 187-197
PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

The accessory lentiviral protein X (Vpx) of the SIV_smm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antiviral targets.

Kei Miyakawa
Satoko Matsunaga
Akihide Ryo
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-12
IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils

The mechanisms mediating lineage restriction in haematopoietic cell differentiation are not well understood. Here the authors show when and how the transcription factor IRF8 inhibits neutrophil differentiation during the lineage selection of monocytes and dendritic cells.

Daisuke Kurotaki
Michio Yamamoto
Tomohiko Tamura
Research19 Sept 2014
Nature Communications

Volume: 5, P: 1-15
Deep learning-based age estimation from chest X-rays indicates cardiovascular prognosis

Ieki et al. train a deep learning model to estimate patients’ age from chest X-ray images. X-ray age is found to be an indicator of poor prognosis in patients with heart failure and patients admitted to the intensive care unit with cardiovascular disease.

Hirotaka Ieki
Kaoru Ito
Issei Komuro
ResearchOpen Access09 Dec 2022
Communications Medicine

Volume: 2, P: 1-12
Transcriptomic profiling of single circulating tumor cells provides insight into human metastatic gastric cancer

Ryo Negishi et al. utilize a size-dependent recovery method with gel-based cell manipulation to isolate single circulating tumor cells (CTCs) for transcriptomic analysis. They demonstrate the utility of this approach by analyzing the transcriptomic profile of CTCs from human gastric cancer patients.

Ryo Negishi
Hitomi Yamakawa
Tomoko Yoshino
ResearchOpen Access11 Jan 2022
Communications Biology

Volume: 5, P: 1-12
Aquarius is required for proper CtIP expression and homologous recombination repair

Ryo Sakasai
Mayu Isono
Kuniyoshi Iwabuchi
ResearchOpen Access23 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
Three-dimensional bonding anisotropy of bulk hexagonal metal titanium demonstrated by high harmonic generation

High harmonics generation (HHG) is a promising way of investigating electronic structures and anisotropy in materials. The authors demonstrate the observation of HHG in simple structural material, hexagonal metal titanium, and experimentally clarified the anisotropy in the electronic states from the polarization dependence.

Ikufumi Katayama
Kento Uchida
Tetsuya Matsunaga
ResearchOpen Access18 Dec 2024
Communications Physics

Volume: 7, P: 1-7
Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Kenya Kusunose
Hisako Yoshida
Mikiko Kagiyama
ResearchOpen Access17 Oct 2021
Hypertension Research

Volume: 45, P: 106-115
Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study

Ryo Kamidani
Takahito Miyake
Shinji Ogura
ResearchOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide

Manabu Kaneko
Yushi Futamura
Koichi Watashi
ResearchOpen Access09 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
Spatial accuracy of dose delivery significantly impacts the planning target volume margin in linear accelerator-based intracranial stereotactic radiosurgery

Yuta Takahashi
Riki Oshika
Hidenobu Tachibana
ResearchOpen Access29 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
Author Correction: The 1-minute sit-to-stand test to detect desaturation during 6-minute walk test in interstitial lung disease

Keiji Oishi
Kazuto Matsunaga
Masafumi Yano
Amendments and CorrectionsOpen Access25 Feb 2022
npj Primary Care Respiratory Medicine

Volume: 32, P: 1
Blood pressure alteration associated with abnormal body electrolyte and water balance in colitis mice

Netish Kumar Kundo
Kento Kitada
Akira Nishiyama
Research10 Sept 2024
Hypertension Research

Volume: 47, P: 3147-3157
High-throughput analysis system of interaction kinetics for data-driven antibody design

Ryo Matsunaga
Kan Ujiie
Kouhei Tsumoto
ResearchOpen Access21 Nov 2023
Scientific Reports

Volume: 13, P: 1-9
Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial

Yuichi Saito
Atsushi Tanaka
Kosuke Nishio
Research14 Nov 2023
Hypertension Research

Volume: 47, P: 168-176
Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation

Shingo Miyata
Manami Kodaka
Jun Inoue
ResearchOpen Access24 May 2022
Scientific Reports

Volume: 12, P: 1-18
Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study

Yuichi Saito
Atsushi Tanaka
Mikiko Kagiyama
ResearchOpen Access05 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Experimental verification of homogeneity in polymer gels

Tetra-PEG gel has highly suppressed heterogeneity, which is considered inherent to conventional polymer gels. In this review, we show a series of experimental results on Tetra-PEG gels, and discuss the homogeneity. Tetra-PEG gel is useful as a model system for examining the model predicting physical properties of polymer gels.

Takamasa Sakai
Reviews28 May 2014
Polymer Journal

Volume: 46, P: 517-523
Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association

Yu Fujinami-Yokokawa
Kaoru Fujinami
Yasuhiro Murakawa
ResearchOpen Access12 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency

Lizhu Yang
Kaoru Fujinami
Yasuhiro Murakawa
ResearchOpen Access26 Mar 2020
Scientific Reports

Volume: 10, P: 1-10

Search

A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts

Direct imaging of atomistic grain boundary migration

Direct observation of substitutional and interstitial dopant diffusion in oxide grain boundary

Hyperthin nanochains composed of self-polymerizing protein shackles

ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

The 1-minute sit-to-stand test to detect desaturation during 6-minute walk test in interstitial lung disease

Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

Factors contributing to discrepant estimated glomerular filtration values measured by creatinine and cystatin C in patients with rheumatoid arthritis

The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein

Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils

Deep learning-based age estimation from chest X-rays indicates cardiovascular prognosis

Transcriptomic profiling of single circulating tumor cells provides insight into human metastatic gastric cancer

Aquarius is required for proper CtIP expression and homologous recombination repair

Three-dimensional bonding anisotropy of bulk hexagonal metal titanium demonstrated by high harmonic generation

Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study

Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide

Spatial accuracy of dose delivery significantly impacts the planning target volume margin in linear accelerator-based intracranial stereotactic radiosurgery

Author Correction: The 1-minute sit-to-stand test to detect desaturation during 6-minute walk test in interstitial lung disease

Blood pressure alteration associated with abnormal body electrolyte and water balance in colitis mice

High-throughput analysis system of interaction kinetics for data-driven antibody design

Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial

Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation

Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study

Experimental verification of homogeneity in polymer gels

Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association

Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency

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