Artificial metalloenzymes are useful catalysts in synthesis, but their use in cells is a challenge. Now, the development of an engineered whole-cell enzymatic cascade, which converts glucose-derived fatty diacids into cycloalkenes, is reported. The cascade process combines a decarboxylase with an artificial metalloenzyme that catalyses an abiotic olefin metathesis reaction.
- Zhi Zou
- Shuke Wu
- Thomas R. Ward
