Nature Search

FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738

Ryuichi Kanasaki
Kazutoshi Sakamoto
Yasuhiro Hori
Research01 Mar 2006
The Journal of Antibiotics

Volume: 59, P: 137-144
FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738

Ryuichi Kanasaki
Fumie Abe
Yasuhiro Hori
Research01 Mar 2006
The Journal of Antibiotics

Volume: 59, P: 145-148
Aggregation State of Molecular Chains and Dynamic Mechanical Behavior of Poly(L-glutamic acid)

Tetsuo Mori
Akihiko Morofuji
Ryuichi Tanaka
Research01 Sept 1979
Polymer Journal

Volume: 11, P: 721-729
FR227673 and FR190293, Novel Antifungal Lipopeptides from Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616

Ryuichi Kanasaki
Motoo Kobayashi
Yasuhiro Hori
Research01 Mar 2006
The Journal of Antibiotics

Volume: 59, P: 158-167
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573

Ryuichi Kanasaki
Fumie Abe
Yasuhiro Hori
Research01 Mar 2006
The Journal of Antibiotics

Volume: 59, P: 149-157
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Bacillus subtilis TO-A suppresses the age-related decline in locomotion in Caenorhabditis elegans

Aged C. elegans fed Bacillus subtilis TO-A (BSTOA) maintain mobility and actin integrity and exhibit increased resistance to oxidative stress. These findings implicate BSTOA-induced maintenance of gpx-7 expression as a key mechanism.

Rika Inomata
Ryuichi Saito
Satoshi Shimazaki
ResearchOpen Access22 Oct 2025
Communications Biology

Volume: 8, P: 1-9
Machine learning-based models for predicting clinical outcomes after surgery in unilateral primary aldosteronism

Hiroki Kaneko
Hironobu Umakoshi
Yoshihiro Ogawa
ResearchOpen Access06 Apr 2022
Scientific Reports

Volume: 12, P: 1-8
Improved clearing method contributes to deep imaging of plant organs

Sakamoto et al. demonstrate an improved optical clearing method, iTOMEI, for plant imaging. The new method can achieve fast clearing and effective removal of autofluorescence signals, and at the same time preserve signals from desired fluorescence proteins.

Yuki Sakamoto
Anna Ishimoto
Sachihiro Matsunaga
ResearchOpen Access10 Jan 2022
Communications Biology

Volume: 5, P: 1-12
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Machine learning based models for prediction of subtype diagnosis of primary aldosteronism using blood test

Hiroki Kaneko
Hironobu Umakoshi
Yoshihiro Ogawa
ResearchOpen Access04 May 2021
Scientific Reports

Volume: 11, P: 1-9
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity

Kohro et al. identify a population of astrocytes located in the superficial dorsal horn of adult spinal cord (genetically defined by Hes5) that acts as a gate for locus coeruleus descending noradrenergic control of mechanosensory hypersensitivity.

Yuta Kohro
Tsuyoshi Matsuda
Makoto Tsuda
Research05 Oct 2020
Nature Neuroscience

Volume: 23, P: 1376-1387
Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression

Megumi Tasaka-Fujita
Nao Sugiyama
Takanobu Kato
ResearchOpen Access14 Sept 2015
Scientific Reports

Volume: 5, P: 1-10
Subtype prediction of primary aldosteronism by combining aldosterone concentrations in the left adrenal vein and inferior vena cava: a multicenter collaborative study on adrenal venous sampling

Yuichi Fujii
Hironobu Umakoshi
Mitsuhide Naruse
Research24 Nov 2017
Journal of Human Hypertension

Volume: 32, P: 12-19
Novel immunotherapy for peritoneal dissemination of murine colon cancer with macrophage inflammatory protein-1β mediated by a tumor-specific vector, HVJ cationic liposomes

Toshio Miyata
Seiji Yamamoto
Yasufumi Kaneda
Research21 Dec 2001
Cancer Gene Therapy

Volume: 8, P: 852-860
Diverse pathological lesions of primary aldosteronism and their clinical significance

Koshiro Nishimoto
Hironobu Umakoshi
Chiba Yoshiro
ResearchOpen Access12 Jan 2021
Hypertension Research

Volume: 44, P: 498-507
Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus

Masashi Hashimoto
Shinji Kuroda
Toshiyoshi Fujiwara
ResearchOpen Access05 Feb 2024
British Journal of Cancer

Volume: 130, P: 1187-1195
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Author Correction: Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus

Masashi Hashimoto
Shinji Kuroda
Toshiyoshi Fujiwara
Amendments and CorrectionsOpen Access14 Oct 2024
British Journal of Cancer

Volume: 131, P: 1716-1717
Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan

Yuichi Fujii
Yoshiyu Takeda
Takahisa Kawaguchi
Research28 Aug 2019
Journal of Human Hypertension

Volume: 34, P: 34-42
A new indole glycoside from Kitasatospora sp. MG372-hF19 carrying a 6-deoxy-α-l-talopyranose moiety

Yasuko Kohda
Shuichi Sakamoto
Manabu Kawada
Research18 Nov 2019
The Journal of Antibiotics

Volume: 73, P: 167-170
Phenazine carboxylic acid and its derivative induce osteoblast differentiation in preosteoblastic MC3T3-E1 cells but adipocyte differentiation in pluripotent mesenchymal C3H10T1/2 cells

Shuichi Sakamoto
Takumi Watanabe
Manabu Kawada
Research25 Oct 2017
The Journal of Antibiotics

Volume: 70, P: 1146-1149
Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells

Shuichi Sakamoto
Fukiko Kojima
Yuzuru Akamatsu
Research13 Oct 2010
The Journal of Antibiotics

Volume: 63, P: 703-708
Correction: Corrigendum: Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression

Megumi Tasaka-Fujita
Nao Sugiyama
Takanobu Kato
Amendments and CorrectionsOpen Access16 Dec 2015
Scientific Reports

Volume: 5, P: 1
Extracting interpretable features for pathologists using weakly supervised learning to predict p16 expression in oropharyngeal cancer

Masahiro Adachi
Tetsuro Taki
Shingo Sakashita
ResearchOpen Access24 Feb 2024
Scientific Reports

Volume: 14, P: 1-12
Association of cardiovascular disease risk and changes in renin levels by mineralocorticoid receptor antagonists in patients with primary aldosteronism

Regarding Japanese primary aldosteronism, the low, intermediate, and high renin change groups (classified based on the response of renin to mineralocorticoid antagonist treatment) had CVD incidence of 2.1%, 0.5%, and 3.7%, respectively, during the 5-year study period.

Motoko Nomura
Isao Kurihara
Chiba Yoshiro
Research28 Jun 2022
Hypertension Research

Volume: 45, P: 1476-1485
Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers

Tsuyoshi Takashima
Daiki Taniyama
Wataru Yasui
Research30 Mar 2021
British Journal of Cancer

Volume: 125, P: 65-77
Brain networks underlying the processing of sound symbolism related to softness perception

Ryo Kitada
Jinhwan Kwon
Maki Sakamoto
ResearchOpen Access01 Apr 2021
Scientific Reports

Volume: 11, P: 1-13
Isolation of new derivatives of the 20-membered macrodiolide bispolide from Kitasatospora sp. MG372-hF19

Yasuko Kohda
Shuichi Sakamoto
Masayuki Igarashi
Research06 Dec 2021
The Journal of Antibiotics

Volume: 75, P: 77-85
Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell

Shoichi Ukai
Ririno Honma
Wataru Yasui
Research12 Oct 2020
Oncogene

Volume: 39, P: 7265-7278
High-risk follicular lymphomas harbour more somatic mutations including those in the AID-motif

Taku Tsukamoto
Masakazu Nakano
Junya Kuroda
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation

Hiroaki Fujimori
Akira Sato
Mitsuko Masutani
ResearchOpen Access15 Dec 2015
Scientific Reports

Volume: 5, P: 1-15
Smad4 is required to inhibit osteoclastogenesis and maintain bone mass

Mayu Morita
Shigeyuki Yoshida
Takeshi Miyamoto
ResearchOpen Access12 Oct 2016
Scientific Reports

Volume: 6, P: 1-11
A hyperaldosteronism subtypes predictive model using ensemble learning

Shigehiro Karashima
Masaki Kawakami
Shozo Miyauchi
ResearchOpen Access21 Feb 2023
Scientific Reports

Volume: 13, P: 1-11
Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism

Shintaro Sakaguchi
Ryuji Okamoto
Mitsuhide Naruse
Research24 Sept 2022
Journal of Human Hypertension

Volume: 37, P: 757-766
Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism

Ryo Nakamaru
Koichi Yamamoto
Daisuke Yabe
ResearchOpen Access25 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
Domain-specific function of ShcC docking protein in neuroblastoma cells

Izumi Miyake
Yuko Hakomori
Ryuichi Sakai
Research21 Feb 2005
Oncogene

Volume: 24, P: 3206-3215

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