The widespread use of screening for circulating anti-neutrophil cytoplasmic autoantibodies (ANCA) in the diagnosis of ANCA-associated vasculitis has resulted in an increased occurrence of false-positive results and greater difficulty in the interpretation of such test results. Therefore, a rational strategy for ANCA testing is needed. The main problems with ANCA testing are discussed in this Viewpoint and some practical guidelines are given.
- Elena Csernok
- Peter Lamprecht
- Wolfgang L Gross
