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How myelin plays a role in long-range processing of disparate inputs remains elusive. Here, the authors show that myelin loss within the neocortex reduces the reliability to propagate cortical bursts across axons, causing an impaired temporal sharpening to compute sensory and cortical signals within the thalamus.

Hole spin qubits in germanium have seen significant advancements, though improving control and noise resilience remains a key challenge. Here, the authors realize a dressed singlet-triplet qubit in germanium, achieving frequency-modulated high-fidelity control and a tenfold increase in coherence time.

Optical computing, involving on-chip integrated logic units, could provide improved performance over semiconductor-based computing. Here, a binary NOR gate is developed from cascaded OR and NOT gates in four-terminal plasmonic nanowire networks; the work could lead to new optical computing technologies.

Parallel operation of two exchange-only qubits consisting of six quantum dots arranged linearly is shown to be achievable and maintains qubit control quality compared with sequential operation, with potential for use in scaled quantum computing.

Quantum gates in 2D ion crystals are more challenging than in 1D. Here, the authors use their 2D ion trap platform and acousto-optical deflectors to demonstrate a 2-qubit gate that can stand the ion micromotion in such configuration.

For solid-state qubits, the material environment hosts sources of errors that vary in time and space. This systematic analysis of errors affecting high-fidelity two-qubit gates in silicon can inform the design of large-scale quantum computers.

Global control of a qubits using a single microwave field is a promising strategy for scalable quantum computing. Here the authors demonstrate individual addressability vial local electrodes and two-qubit gates in an array of Si quantum dot spin qubits dressed by a global microwave field and driven on-resonance.

Energy homeostasis requires brain sensing of peripheral metabolic signals. Here, the authors show that energy-state-dependent aggrecan deposits by hypothalamic neurons at a key interface gate brain entry of blood-borne signals and thus food intake.

Initiation factor 2 (IF2) guides the ribosome to the elongation phase of protein synthesis. Here, Basu et al. provide structural insights into how compact IF2-GDP makes way for initiator tRNA accommodation into the peptidyl (P) site of the ribosome.

Experimental realizations of discrete time crystals have mainly involved 1D models with Ising-like couplings. Here, the authors realize a 2D discrete time crystal with anisotropic Heisenberg coupling on a quantum simulator based on superconducting qubits, uncovering a rich phase diagram.

How and where somatosensory information is encoded in the cortex is unclear and important for developing new pain therapies. Here the authors show a crucial role for the secondary somatosensory cortex (S2) in accurate perception of sensory stimuli.

Measurement-based quantum computing performs quantum gates on entangled states without difficult multi-qubit coherent dynamics. A set of gates sufficient for universal quantum computing has now been implemented on a programmable optical platform.

Glutamate transporters conduct chloride ions through an aqueous channel with hydrophobic gates that forms during the glutamate transport cycle.

Ultracold atoms in optical lattices are promising for quantum information applications, but it is important to address individual sites with high accuracy and low cross-talk. Lee et al.adapt inhomogeneous control methods to improve the performance of single-qubit gates for selected sites.

Store-operated calcium entry involves two proteins: Stim1 and Orai1, but are they sufficient for gating CRAC channels or are other factors required? Mammal systems have failed to provide a conclusive answer but yeast-based assay does: Stim1 and Orai1 are the only essential components of CRAC channel activity.

A brief (maximum 250 characters, including spaces) summary; Please provide this summary in your cover letter. Animals often promote visual aversion in a threatening situation for survival. Tsuji et al. report in Drosophila that a single cluster of Tachykinergic neurons translate mechanical threats to gating of visual aversion through θ oscillation.

By using carbon nanotubes as a channel material, an ion gel as a gate and polyimide as a substrate, field-effect transistors can be created that have a high radiation tolerance and can be repaired by annealing.

Tanycytic insulin receptors allow insulin access to the hypothalamic arcuate nucleus and are relevant for driving AgRP neuronal activity in response to feeding.

The central amygdala relies on inhibitory circuitry to encode fear memories, but how this information is acquired and expressed in these connections is unknown. Two new papers use a combination of cutting-edge technologies to reveal two distinct microcircuits within the central amygdala, one required for fear acquisition and the other critical for conditioned fear responses. Understanding this architecture provides a strong link between activity in a specific circuit and particular behavioural consequences.

Spin qubits are a platform for quantum computing. There are many advantages for quantum information processing if the spin qubit can move. Here, Helgers et al. use a surface acoustic wave to define a moving quantum dot and demonstrate the magneticfield-free control of the spin precession, bringing “flying” spin qubits a step closer.

Enduring changes in synaptic efficacy are highly sensitive to stress. Here, the authors show that astrocytic delivery of metabolites has an important role in the stress-mediated impairment of synaptic plasticity.

Scaling Si spin qubits relies on the uniform control of qubit-host interactions. This work finds correlations in qubit energy levels across a manufactured device arising from placement of Ge in the quantum well, consistent with atomistic modeling.

Hole spin semiconductor qubits suffer from charge noise, but now it has been demonstrated that placing them in an appropriately oriented magnetic field can suppress this noise and improve qubit performance.

Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2.

Although ABC-F proteins represent a ubiquitously distributed type of ATP-binding cassette (ABC) family member across phyla, their biological functions remain poorly characterized. A new study now shows that the bacterial ABC-F protein YjjK (EttA) gates ribosome entry into the translational cycle in an energy-dependent manner.

Researchers describe a mechanism capable of compressing fast and intense X-ray pulses through the rapid loss of crystalline periodicity. It is hoped that this concept, combined with X-ray free-electron laser technology, will allow scientists to obtain structural information at atomic resolutions.

Seamless integration of decoherence protection into quantum logic gates has enabled high-fidelity execution of a quantum algorithm with individual spins in a hybrid quantum system.

Microwave stimulation of a superconducting artificial three-level atom is used to demonstrate high-fidelity, non-Abelian geometric transformations, the results of which depend on the order in which they are performed.

The growing complexity of quantum computing devices makes presents challenges for benchmarking their performance as previous, exhaustive approaches become infeasible. Here the authors characterise the quality of their 11-qubit device by successfully computing two quantum algorithms.

Grover’s algorithm provides a quantum speedup when searching through an unsorted database. Here, the authors perform it on 3 qubits using trapped ions, demonstrating two methods for marking the correct result in the algorithm’s oracle and providing data for searches yielding 1 or 2 solutions.

The PCRCR complex of Plasmodium spp. binds basigin on the erythrocyte surface. While Rh5 of the complex is restricted to P. falciparum, PTRAMP, CSS and Ripr orthologs are present across the genus, for which the authors report common features.

Quantum dot spin qubits in Si can be controlled using micromagnet-based electric-dipole spin resonance, but experiments have been limited to small 1D arrays. Here the authors address qubit control in 2D Si arrays, demonstrating low-frequency control of qubits in a 2 x 2 array using hopping gates.

Two-qubit logic gates in a silicon-based system are shown (using randomized benchmarking) to have high gate fidelities of operation and are used to generate Bell states, a step towards solid-state quantum computation.

Several transmission-blocking vaccine candidates based on Pfs230 and Pfs48/45 are in clinical development, but it remains unclear whether they will demonstrate high efficacy. Here, the authors develop a stabilized chimeric antigen presenting potent epitopes from Pfs230 and Pfs48/45 in a single construct and demonstrate induction of transmission-reducing antibodies when female mice are immunized with the antigen in a self-assembling protein nanoparticle formulation.

Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene regulatory networks to identify lineage restriction within multilineage progenitors.

Controlled nanophotonic fabrication in silicon carbide enables the quantum manipulation of nuclear spins with optical and spin coherence comparable to the pristine material, setting the ground for scalable integrated quantum networks.

Using a cryogenic 300-mm wafer prober, a new approach for the testing of hundreds of industry-manufactured spin qubit devices at 1.6 K provides high-volume data on performance, allowing optimization of the complementary metal–oxide–semiconductor (CMOS)-compatible fabrication process.

This study describes design automation and predictable gene regulatory network engineering in a eukaryotic microorganism.

Characterisation of quantum operations is fundamental in quantum technologies - quantum computing in particular - but there’s currently no reliably efficient method to assess mid-circuit measurements, which are a key component for subfields like quantum error correction. Here, the authors fill this gap, integrating MCMs into the framework of randomized benchmarking.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.