Nature Search

Ether lipids influence cancer cell fate by modulating iron uptake

The contribution of ether lipid species in cancer cell fate has not been fully understood yet. Here the authors show that malignant cancer cells employ ether lipids to modulate membrane biophysical properties, enhancing iron endocytosis and ferroptosis susceptibility.

Ryan P. Mansell
Sebastian Müller
Whitney S. Henry
ResearchOpen Access27 Jan 2026
Nature Communications

P: 1-19
Signal-transduction

GUY ST J. WHITLEY
JAMES F. TAIT
Research15 Jan 1987
Nature

Volume: 325, P: 201
Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding

One way to reduce obesity is to alter fat absorption from the diet. Here Robert Farese, Jr. and his colleagues identify MGAT2 as a potential therapeutic target for doing so. The enzyme is mostly expressed in the gut of humans and mice, and its genetic deletion in mice results in slower kinetics of fat absorption—more of the fat is burned and less is stored, offering protection from diet-induced obesity.

Chi-Liang Eric Yen
Mei-Leng Cheong
Robert V Farese Jr
Research15 Mar 2009
Nature Medicine

Volume: 15, P: 442-446
Chemically induced myotonia in amphibia

A. H. Bretag
S. R. Dawe
A. G. Moskwa
Research07 Aug 1980
Nature

Volume: 286, P: 625-626
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia, and there is currently no treatment. Here, the authors report and utilize small molecule positive regulators of GRN expression to boost progranulin levels from the remaining functional GRN allele, thus restoring progranulin levels back to normal within the brain.

Rachel Tesla
Charlotte Guhl
Joachim Herz
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-20
A flat Universe from high-resolution maps of the cosmic microwave background radiation

P. de Bernardis
P. A. R. Ade
N. Vittorio
Research27 Apr 2000
Nature

Volume: 404, P: 955-959
Corrigendum: Therapeutic potential of monovalent monoclonal antibodies

S. P. Cobbold
H. Waldmann
Research07 Jun 1984
Nature

Volume: 309, P: 564
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.

Sebastian Boland
Sharan Swarup
Robert V. Farese Jr
ResearchOpen Access07 Oct 2022
Nature Communications

Volume: 13, P: 1-13
Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme

Cryo-electron microscopy structures and functional and mutagenesis studies provide insights into the catalysis of triacylglycerol synthesis by human acyl-CoA diacylglycerol acyltransferase at its intramembrane active site.

Xuewu Sui
Kun Wang
Robert V. Farese Jr
Research13 May 2020
Nature

Volume: 581, P: 323-328
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat

Joakim Galli
Luo-Sheng Li
Holger Luthman
Research01 Jan 1996
Nature Genetics

Volume: 12, P: 31-37
Functional selectivity of GPCR-directed drug action through location bias

Intracellular G_s-cAMP signaling from β₁-adrenergic receptors residing in the Golgi represents ‘location bias’, a new form of GPCR functional selectivity. Inactive Golgi-localized receptors can be activated by some β₁-targeting drugs.

Roshanak Irannejad
Veronica Pessino
Mark von Zastrow
Research29 May 2017
Nature Chemical Biology

Volume: 13, P: 799-806
Embryology of vestimentiferan tube worms from deep-sea methane/sulphide seeps

Craig M. Young
Elsa Vázquez
Paul A. Tyler
Research06 Jun 1996
Nature

Volume: 381, P: 514-516
Tumor Necrosis Factor-α, Interleukin-1β, and Interleukin-6 Plasma Levels in Neonatal Sepsis

E S J M De Bont
A Martens
L H F M De Leij
Research01 Apr 1993
Pediatric Research

Volume: 33, P: 380-383
It pays to be different

J. S. Jones
Paul H. Harvey
News & Views13 Aug 1987
Nature

Volume: 328, P: 575-576
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

Eukaryotic cells store neutral lipids in cytoplasmic lipid droplets. Processes regulating the formation of these organelles are at present unknown. A genome-wide RNAi screen in Drosophila cells identifies genes involved in lipid droplet formation and utilization, finding that 1% of all genes are involved in these processes. This study will lead to an understanding of human diseases involving excessive lipid storage.

Yi Guo
Tobias C. Walther
Robert V. Farese
Research13 Apr 2008
Nature

Volume: 453, P: 657-661
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

In the absence of progranulin, microglia enter a disease-specific state that causes endolysosomal dysfunction and neurodegeneration, and these microglia promote TDP-43 granule formation, nuclear pore defects and cell death specifically in excitatory neurons via the complement activation pathway.

Jiasheng Zhang
Dmitry Velmeshev
Eric J. Huang
Research31 Aug 2020
Nature

Volume: 588, P: 459-465
Lipid droplets and liver disease: from basic biology to clinical implications

Lipid droplets (LDs) are dynamic organelles and many metabolic disorders results in abnormal lipid accumulation in the liver. This Review provides insights into LD biology and lipid homeostasis in the liver, as well as the role of LDs in liver diseases, including NAFLD, NASH and hepatitis C.

Nina L. Gluchowski
Michel Becuwe
Robert V. Farese Jr
Reviews21 Apr 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 14, P: 343-355
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

Progranulin overexpression in Alzheimer's disease model mice protects against neuronal loss and enhances cognitive deficits.

S Sakura Minami
Sang-Won Min
Li Gan
Research28 Sept 2014
Nature Medicine

Volume: 20, P: 1157-1164
Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs)

Maria A. Recuero-Checa
Manu Sharma
Deborah Dean
ResearchOpen Access18 Mar 2016
Scientific Reports

Volume: 6, P: 1-15
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice

Kimberly K. Buhman
Michel Accad
Robert V. Farese Jr.
Research01 Dec 2000
Nature Medicine

Volume: 6, P: 1341-1347
Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

Cryo-electron microscopy of neddylated SCF-family ligases interacting with the RBR-type E3 ligase ARIH1 reveals the steps through which E3–E3 super-assemblies ubiquitylate a diverse set of substrates presented on F-box proteins.

Daniel Horn-Ghetko
David T. Krist
Brenda A. Schulman
ResearchOpen Access03 Feb 2021
Nature

Volume: 590, P: 671-676
Insulin suppression of fatty acid skeletal muscle enzyme activity in postmenopausal women, and improvements in metabolic flexibility and lipoprotein lipase with aerobic exercise and weight loss

Alice S. Ryan
Heidi K. Ortmeyer
Research15 Jun 2018
International Journal of Obesity

Volume: 43, P: 276-284
The biophysics and cell biology of lipid droplets

Lipid droplets are intracellular organelles that store oil-based reserves of metabolic energy and components of membrane lipids. Basic biophysical principles of emulsions are important for lipid droplet biology, their formation, growth and shrinkage. Such mechanisms enable cells to use emulsified oil when required. The surfactant composition at the lipid droplet surface is crucial for homeostasis and protein targeting to their surfaces.

Abdou Rachid Thiam
Robert V. Farese Jr
Tobias C. Walther
Reviews13 Nov 2013
Nature Reviews Molecular Cell Biology

Volume: 14, P: 775-786
Acyl-Coenzyme A:Cholesterol Acyltransferase 2 (ACAT2) Is Induced in Monocyte-Derived Macrophages: In Vivo and In Vitro Studies

Naomi Sakashita
Akira Miyazaki
Motohiro Takeya
Research01 Nov 2003
Laboratory Investigation

Volume: 83, P: 1569-1581
Platelet transfusion requirements during autologous peripheral blood progenitor cell transplantation correlate with the pretransplant platelet count

BJ Bolwell
M Goormastic
M Kalaycio
Research01 Sept 1997
Bone Marrow Transplantation

Volume: 20, P: 459-463
Protein kinase Cα activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase

Francesco Andreozzi
Rosa Marina Melillo
Pietro Formisano
Research15 May 2003
Oncogene

Volume: 22, P: 2942-2949
Co-segregation of elevated LDL with a novel mutation (D92K) of the LDL receptor in a kindred with multiple lipoprotein abnormalities

L. L. Wu
P. N. Hopkins
M. Emi
Research01 May 2000
Journal of Human Genetics

Volume: 45, P: 154-158
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

During fasting SIRT3 is induced in liver and brown adipose tissue. One of SIRT3's substrates is shown to be long–chain acyl co-enzyme A dehydrogenase (LCAD). Without SIRT3 LCAD becomes hyperacetylated, which diminishes its activity, and reduces fatty acid oxidation. Mice without SIRT3 have all the hallmarks of fatty acid oxidation disorders during fasting, including reduced ATP levels and intolerance to cold. Thus, acetylation is a novel regulatory mechanism for fatty acid oxidation.

Matthew D. Hirschey
Tadahiro Shimazu
Eric Verdin
Research04 Mar 2010
Nature

Volume: 464, P: 121-125
Liquorice-induced rise in blood pressure: a linear dose-response relationship

H Á Sigurjónsdóttir
L Franzson
S Wallerstedt
Research06 Aug 2001
Journal of Human Hypertension

Volume: 15, P: 549-552
A guide to analysis of mouse energy metabolism

Authors present workflows for the analysis of metabolism phenotypes in mice and recommend analysis of covariance to asses body composition effects.

Matthias H Tschöp
John R Speakman
Eric Ravussin
Reviews28 Dec 2011
Nature Methods

Volume: 9, P: 57-63
Expression of α_vβ₆integrin in oral leukoplakia

S Hamidi
T Salo
H Larjava
ResearchOpen Access21 Mar 2000
British Journal of Cancer

Volume: 82, P: 1433-1440
NSAID treatment with meloxicam enhances peripheral stem cell mobilization in myeloma

B Jeker
U Novak
T Pabst
Research23 Oct 2017
Bone Marrow Transplantation

Volume: 53, P: 175-179
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Inhibition of HECT E3 ligases as potential therapy for COVID-19

Giuseppe Novelli
Jing Liu
Pier Paolo Pandolfi
ResearchOpen Access24 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-18
The impact of ABCC11 polymorphisms on the risk of early-onset fluoropyrimidine toxicity

S Hamzic
N Wenger
U Amstutz
Research22 Mar 2016
The Pharmacogenomics Journal

Volume: 17, P: 319-324
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Ether lipids influence cancer cell fate by modulating iron uptake

Signal-transduction

Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding

Chemically induced myotonia in amphibia

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

A flat Universe from high-resolution maps of the cosmic microwave background radiation

Corrigendum: Therapeutic potential of monovalent monoclonal antibodies

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme

Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat

Functional selectivity of GPCR-directed drug action through location bias

Embryology of vestimentiferan tube worms from deep-sea methane/sulphide seeps

Tumor Necrosis Factor-α, Interleukin-1β, and Interleukin-6 Plasma Levels in Neonatal Sepsis

It pays to be different

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

Lipid droplets and liver disease: from basic biology to clinical implications

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs)

Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice

Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

Insulin suppression of fatty acid skeletal muscle enzyme activity in postmenopausal women, and improvements in metabolic flexibility and lipoprotein lipase with aerobic exercise and weight loss

The biophysics and cell biology of lipid droplets

Acyl-Coenzyme A:Cholesterol Acyltransferase 2 (ACAT2) Is Induced in Monocyte-Derived Macrophages: In Vivo and In Vitro Studies

Platelet transfusion requirements during autologous peripheral blood progenitor cell transplantation correlate with the pretransplant platelet count

Protein kinase Cα activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase

Co-segregation of elevated LDL with a novel mutation (D92K) of the LDL receptor in a kindred with multiple lipoprotein abnormalities

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

Liquorice-induced rise in blood pressure: a linear dose-response relationship

A guide to analysis of mouse energy metabolism

Expression of α_vβ₆integrin in oral leukoplakia

NSAID treatment with meloxicam enhances peripheral stem cell mobilization in myeloma

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Inhibition of HECT E3 ligases as potential therapy for COVID-19

The impact of ABCC11 polymorphisms on the risk of early-onset fluoropyrimidine toxicity

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Search

Quick links

Search

Filter By:

Search

Quick links