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Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation

Energetic profiling of cryo-EM time series for IAPP, tau, and α-synuclein reveals how amyloid fibril maturation is driven by sequence-encoded hotspots. Rearrangement of APRs anchors growth, while cofactors relieve strain, enabling polymorphic diversity.

Ramon Duran-Romaña
Joost Schymkowitz
Nikolaos Louros
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome

Dysregulated protein synthesis is key contributor to Fragile X syndrome. Here the authors identify a relationship between ribosome expression and the translation of long mRNAs that contributes to synaptic weakening in a model of Fragile X syndrome.

Sang S. Seo
Susana R. Louros
Emily K. Osterweil
ResearchOpen Access10 Jun 2022
Nature Communications

Volume: 13, P: 1-18
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell death, which could serve as antibacterial strategy.

Ladan Khodaparast
Laleh Khodaparast
Joost Schymkowitz
ResearchOpen Access28 Feb 2018
Nature Communications

Volume: 9, P: 1-15
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability

G. L. Caldeira
A. S. Inácio
A. L. Carvalho
ResearchOpen Access07 Mar 2022
Molecular Psychiatry

Volume: 27, P: 2457-2469

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Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation

Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability

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