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Showing 1–4 of 4 results
Advanced filters: Author: Saba Rezakhani Clear advanced filters

  • The influence of stress relaxation of the extracellular matrix on the formation of intestinal organoids was investigated. It was shown that a stress-relaxing synthetic matrix promotes crypt budding through increased symmetry breaking and niche cell formation.

    • Antonius Chrisnandy
    • Delphine Blondel
    • Matthias P. Lutolf
    Research
    Nature Materials
    Volume: 21, P: 479-487

  • 3D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix stiffness and organoid growth that does not require acto-myosin contraction.

    • Giovanni Sorrentino
    • Saba Rezakhani
    • Kristina Schoonjans
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10