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Advanced filters: Author: Saket Awadhesbhai Patel Clear advanced filters

Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits

Extracellular vesicles (EVs) mediate intercellular communication by transferring signaling macromolecules. Unexpectedly, the author here identifies that adipocyte-specific loss of SMPD3 triggers neighboring preadipocytes to release EVs containing SMPD3 mRNA, restoring SMPD3 expression in genetically null adipocytes.

Clair Crewe
Christy M. Gliniak
Philipp E. Scherer
ResearchOpen Access11 Apr 2026
Nature Communications

P: 1-12
One-pot synthesis of cyclic-aminotropiminium carboxylate derivatives with DNA binding and anticancer properties

Tropolones harbor a non-benzenoid aromatic scaffold and display a wide-range of bioactivities, however, the cyclic derivatives of aminotroponimines remain underexplored. Here, the authors develop a one-pot synthesis of N^Alkyl/C^Aryl-substituted cyclic-aminotropiminium carboxylate derivatives with promising anticancer properties.

Bibhuti Bhusana Palai
Saket Awadhesbhai Patel
Manjusha Dixit
ResearchOpen Access27 Dec 2022
Communications Chemistry

Volume: 5, P: 1-16
EEF1A2 promotes HIF1A mediated breast cancer angiogenesis in normoxia and participates in a positive feedback loop with HIF1A in hypoxia

Saket Awadhesbhai Patel
Md. Khurshidul Hassan
Manjusha Dixit
Research27 Nov 2023
British Journal of Cancer

Volume: 130, P: 184-200

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