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Pathology-oriented multiplexing enables integrative disease mapping

Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

Malte Kuehl
Yusuke Okabayashi
Victor G. Puelles
ResearchOpen Access18 Jul 2025
Nature

Volume: 644, P: 516-526
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

The bacterium Helicobacter pylori, often found in the human stomach, can be classified into distinct subpopulations associated with the geographic origin of the host. Here, the authors provide insights into H. pylori population structure by collecting over 1,000 clinical strains from 50 countries and generating and analyzing high-quality bacterial genome sequences.

Kaisa Thorell
Zilia Y. Muñoz-Ramírez
Charles S. Rabkin
ResearchOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1-16
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
The structure of genotype-phenotype maps makes fitness landscapes navigable

In realistic high-dimensional fitness landscapes of RNA secondary structure, protein tertiary structure and protein complexes, fitness peaks can be easily reached from any starting point without traversing fitness valleys.

Sam F. Greenbury
Ard A. Louis
Sebastian E. Ahnert
Research29 Sept 2022
Nature Ecology & Evolution

Volume: 6, P: 1742-1752
Novel CMKLR1 Inhibitors for Application in Demyelinating Disease

Vineet Kumar
Melissa LaJevic
Brian A. Zabel
ResearchOpen Access09 May 2019
Scientific Reports

Volume: 9, P: 1-13

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Pathology-oriented multiplexing enables integrative disease mapping

Genomic investigations of unexplained acute hepatitis in children

The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Adeno-associated virus 2 infection in children with non-A–E hepatitis

The structure of genotype-phenotype maps makes fitness landscapes navigable

Novel CMKLR1 Inhibitors for Application in Demyelinating Disease

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