Gene expression changes that occur in the brains of people with depression could lead to the development of new therapies. Now, Ronald Duman and his colleagues report that the phosphatase Mkp-1 is upregulated in the postmortem hippocampus of individuals with depression, and altering the expression of this protein in rats and mice can regulate depressive behaviors and their resistance to stress.
- Vanja Duric
- Mounira Banasr
- Ronald S Duman
