In ancestral SARS-CoV-2 infection, NK cell interferon-stimulated gene (ISG)-driven activation correlated with poor antibody breadth. In vitro, NK cell ISG expression boosts cytotoxicity toward TFH-like cells, suggesting a mechanism for impaired antibody responses.
- Izumi de los Rios Kobara
- Radeesha Jayewickreme
- Catherine A. Blish
