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Advanced filters: Author: Sanak Banerjee Clear advanced filters

Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration

During collective migration, only a few cells become leaders that guide tissue movement. Here, the authors show that contractile forces drive lysosomes to the cell edge, where they activate Rac1 and trigger leader cell emergence.

Rituraj Marwaha
Diya Manoj
Tamal Das
ResearchOpen Access21 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode

Rawal et al. combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration.

Simran Rawal
Pradeep Keshavanarayana
Tamal Das
ResearchOpen Access18 Aug 2025
Nature Cell Biology

Volume: 27, P: 1660-1675

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Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration

Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode

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