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Showing 1–3 of 3 results
Advanced filters: Author: Sangkyeong Eom Clear advanced filters

  • CRISPR–Cas9 in Streptococcus pyogenes prevents self-cleavage through abasic CRISPR RNA oxidations that suppress off-target activity. Inspired by a natural mechanism, Gu and Kim et al. designed chemically modified abasic guide RNAs to enhance genome-editing specificity of SpCas9, suppressing off-target toxicity in in vivo applications.

    • Dowoon Gu
    • Geun-Woo D. Kim
    • Sung Wook Chi
    Research
    Nature Chemical Biology
    P: 1-12