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Showing 1–7 of 7 results
Advanced filters: Author: Sangsu Bang Clear advanced filters

  • In this study, Wrigth et al. use structural, medicinal chemistry, and behavioral approaches to examine how equilibrative nucleoside transporter subtype 1 (ENT1) exerts its functions; and their findings reveal ENT1 as a potential target for analgesia.

    • Nicholas J. Wright
    • Yutaka Matsuoka
    • Seok-Yong Lee
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • There is an unmet clinical need to develop therapies to alleviate metastatic bone pain, frequently observed in patients with advanced cancers. Here, using mouse models of bone cancer pain, the authors show that STING agonists not only suppress bone cancer tumor burden, but also attenuate bone pain and reduce cancer-induced bone destruction.

    • Kaiyuan Wang
    • Christopher R. Donnelly
    • Ru-Rong Ji
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • The membrane protein TMC-1 is required for salt avoidance behaviour in C. elegans, functions as an ion channel directly activated by NaCl in vitro and is a candidate salt chemosensor; the human homologue of TMC-1 is linked to deafness and may be the cochlear hair-cell mechanotransduction channel.

    • Marios Chatzigeorgiou
    • Sangsu Bang
    • William R. Schafer
    Research
    Nature
    Volume: 494, P: 95-99

  • Toll-like receptor 5 (TLR5) expression is found to be enriched in mouse dorsal root ganglion (DRG) A-fiber neurons known to mediate mechanical allodynia, a form of chronic neuropathic pain. Selective silencing of both mouse and human DRG A-fiber neurons is achieved by co-application of the TLR5 ligand flagellin and the lidocaine derivative QX-314, which is also sufficient to reverse mechanical allodynia in three different mouse models of chronic neuropathic pain.

    • Zhen-Zhong Xu
    • Yong Ho Kim
    • Ru-Rong Ji
    Research
    Nature Medicine
    Volume: 21, P: 1326-1331