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Showing 1–16 of 16 results
Advanced filters: Author: Sarah C. Heilshorn Clear advanced filters

  • Human pluripotent stem cell-derived in vitro models have potential as tools to study aspects of human brain development. Here, Heilshorn and colleagues review biomaterial-based approaches that may be integrated into these models in an effort to develop them further and better recapitulate neurodevelopmental processes.

    • Julien G. Roth
    • Michelle S. Huang
    • Sarah C. Heilshorn
    Reviews
    Nature Reviews Neuroscience
    Volume: 22, P: 593-615

  • Maintaining neural progenitor cell stemness has proven challenging in vitro, due to their propensity to form cell-dense neurospheres. Here, the authors developed a 3D hydrogel system that supports neural progenitor cell stemness maintenance and differentiation by tuning matrix mechanics and cell-binding cues, enabling long-term expansion and neuron formation without needing dense cell clusters.

    • Michelle S. Huang
    • Bauer L. LeSavage
    • Sarah C. Heilshorn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Bioprinting has potential in the biofabrication of three dimensional tissues, but is poorly suited to the manipulation of neural organoids. Here, the authors develop a bioprinting platform to allow the arrangement of organoids to form assembloids.

    • Julien G. Roth
    • Lucia G. Brunel
    • Sarah C. Heilshorn
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Transcriptomic and proteomic analyses show that high levels of the extracellular-matrix protein osteopontin are associated with the attenuated foreign-body response elicited by breast silicone implants wrapped with acellular dermal matrix.

    • Michelle F. Griffin
    • Jennifer B. Parker
    • Michael T. Longaker
    Research
    Nature Biomedical Engineering
    Volume: 9, P: 1254-1275

  • An immune cell population enriched in inflamed gut tissue is shown to play a role in driving CD44+ intestinal organoid proliferation, while also regulating extracellular matrix deposition and remodelling in a synthetic hydrogel platform.

    • Bauer L. LeSavage
    • Sarah C. Heilshorn
    News & Views
    Nature Materials
    Volume: 20, P: 124-125

  • Autosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder which is associated with kidney and liver pathology, including liver fibrosis. Here the authors develop and characterize human liver organoids with a ARPKD mutation, and find that they show aspects of the pathology, including fibrosis.

    • Yuan Guan
    • Annika Enejder
    • Gary Peltz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Organoids are 3D cell culture systems that mimic the structural and functional characteristics of organs. In this Review, the authors discuss the biochemical and mechanical material properties relevant for organoid formation and highlight materials designed with the aim to establish organoid cultures as powerful research platforms.

    • Michael J. Kratochvil
    • Alexis J. Seymour
    • Sarah C. Heilshorn
    Reviews
    Nature Reviews Materials
    Volume: 4, P: 606-622

  • Integrating bioprinting with organoid technology can enhance tissue engineering by improving complexity, reproducibility and scalability. This Review discusses living materials in bioprinting, current organoid bioprinting methods, support baths and future innovations that could advance complex tissue development and applications.

    • Michelle S. Huang
    • Fotis Christakopoulos
    • Sarah C. Heilshorn
    Reviews
    Nature Reviews Bioengineering
    Volume: 3, P: 126-142

  • This Review summarizes limitations in the current techniques used for patient-derived cancer organoid culture and highlights recent advancements and future opportunities for their standardization.

    • Bauer L. LeSavage
    • Riley A. Suhar
    • Sarah C. Heilshorn
    Reviews
    Nature Materials
    Volume: 21, P: 143-159