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Advanced filters: Author: Sarah K. Rempel Clear advanced filters

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

The COP9 signalosome (CSN) regulates Cullin-RING Ligase 2 (CRL2) but the molecular basis for their interaction is unknown. Here the authors use structural mass spectrometry and cryo-EM approaches to assess the structures and dynamics of CSN-CRL2 complexes.

Sarah V. Faull
Andy M. C. Lau
Argyris Politis
ResearchOpen Access23 Aug 2019
Nature Communications

Volume: 10, P: 1-13
RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex

Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance.

Timothy S. Catlett
Massimo M. Onesto
Timothy M. Gómez
ResearchOpen Access10 May 2021
Nature Communications

Volume: 12, P: 1-15
Regional patterns and climatic predictors of viruses in honey bee (Apis mellifera) colonies over time

Alison McAfee
Niloofar Alavi-Shoushtari
Leonard J. Foster
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-21

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