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Advanced filters: Author: Saskia M. Brachmann Clear advanced filters

Identification and characterization of binders to a cryptic and functional pocket in KRAS

In this work, Beyer and colleagues have utilized display screening technologies to comprehensively chart RAS proteins “druggability” and in doing so unravel a targetable ligand-induced pocket in RAS opening unprecedented anti-RAS targeted opportunities.

Kim S. Beyer
Jessica Klein
Sauveur-Michel Maira
ResearchOpen Access02 Dec 2025
Nature Communications

Volume: 16, P: 1-15
Author Correction: Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers

Emilie A. Chapeau
Laurent Sansregret
Tobias Schmelzle
Amendments and CorrectionsOpen Access17 Jun 2024
Nature Cancer

Volume: 5, P: 1130
Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers

Chapeau et al. develop a nonallosteric inhibitor of the interaction between YAP and all four TEAD proteins. Treatment with the inhibitor, either as monotherapy or in combination with other treatment modalities, leads to induction of cell death in several in vivo cancer models.

Emilie A. Chapeau
Laurent Sansregret
Tobias Schmelzle
ResearchOpen Access02 Apr 2024
Nature Cancer

Volume: 5, P: 1102-1120

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